Polarized Expression of p75NTR specifies axons during development and adult neurogenesis

Emanuela Zuccaro, Matteo Bergami, Beatrice Vignoli, Guillaume Bony, Brian A. Pierchala, Spartaco Santi, Laura Cancedda, Marco Canossa

Research output: Contribution to journalArticlepeer-review

Abstract

Newly generated neurons initiate polarizing signals that specify a single axon and multiple dendrites, aprocess critical for patterning neuronal circuits invivo. Here, we report that the pan-neurotrophin receptor p75NTR is a polarity regulator that localizes asymmetrically in differentiating neurons in response to neurotrophins and is required for specification of the future axon. In cultured hippocampal neurons, local exposure to neurotrophins causes early accumulation of p75NTR into one undifferentiated neurite to specify axon fate. Moreover, knockout or knockdown of p75NTR results in failure to initiate an axon in newborn neurons upon cell-cycle exit invitro and in the developing cortex, as well as during adult hippocampal neurogenesis invivo. Hence, p75NTR governs neuronal polarity, determining pattern and assembly of neuronal circuits in adult hippocampus and cortical development.

Original languageEnglish
Pages (from-to)138-152
Number of pages15
JournalCell Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Oct 4 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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