Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue

Michele Salemi, A. Galia, F. Fraggetta, C. La Corte, P. Pepe, S. La Vignera, G. Improta, P. Bosco, A. E. Calogero

Research output: Contribution to journalArticlepeer-review

Abstract

A genetic background has been implicated in the development of prostate cancer. Protein microarrays have enabled the identification of proteins, some of which associated with apoptosis, that may play a role in the development of such a tumor. Inhibition of apoptosis is a co-factor that contributes to the onset and progression of prostate cancer, though the molecular mechanisms are not entirely understood. Poly (ADP-ribose) polymerase 1 (PARP-1) gene is required for translocation of the apoptosis-inducing factor (AIF) from the mitochondria to the nucleus. Hence, it is involved in programmed cell death. Different PARP-1 gene expression has been observed in various tumors such as glioblastoma, lung, ovarian, endometrial, and skin cancers. We evaluated the expression of PARP-1 protein in prostatic cancer and normal prostate tissues by immunohistochemistry in 40 men with prostate cancer and in 37 normal men. Positive nuclear PARP-1 staining was found in all samples (normal prostate and prostate cancer tissues). No cytoplasmic staining was observed in any sample. PARP-1-positive cells resulted significantly higher in patients with prostate carcinoma compared with controls (P

Original languageEnglish
Pages (from-to)80-82
Number of pages3
JournalEuropean journal of histochemistry : EJH
Volume57
Issue number2
DOIs
Publication statusPublished - Apr 15 2013

Keywords

  • Immunoistochemistry
  • PARP-1gene
  • Prostate cancer
  • Proteinexpression

ASJC Scopus subject areas

  • Cell Biology
  • Histology
  • Biophysics

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