Abstract
A genetic background has been implicated in the development of prostate cancer. Protein microarrays have enabled the identification of proteins, some of which associated with apoptosis, that may play a role in the development of such a tumor. Inhibition of apoptosis is a co-factor that contributes to the onset and progression of prostate cancer, though the molecular mechanisms are not entirely understood. Poly (ADP-ribose) polymerase 1 (PARP-1) gene is required for translocation of the apoptosis-inducing factor (AIF) from the mitochondria to the nucleus. Hence, it is involved in programmed cell death. Different PARP-1 gene expression has been observed in various tumors such as glioblastoma, lung, ovarian, endometrial, and skin cancers. We evaluated the expression of PARP-1 protein in prostatic cancer and normal prostate tissues by immunohistochemistry in 40 men with prostate cancer and in 37 normal men. Positive nuclear PARP-1 staining was found in all samples (normal prostate and prostate cancer tissues). No cytoplasmic staining was observed in any sample. PARP-1-positive cells resulted significantly higher in patients with prostate carcinoma compared with controls (P
| Original language | English |
|---|---|
| Pages (from-to) | 80-82 |
| Number of pages | 3 |
| Journal | European journal of histochemistry : EJH |
| Volume | 57 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 15 2013 |
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Keywords
- Immunoistochemistry
- PARP-1gene
- Prostate cancer
- Proteinexpression
ASJC Scopus subject areas
- Cell Biology
- Histology
- Biophysics
Cite this
Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue. / Salemi, Michele; Galia, A.; Fraggetta, F.; La Corte, C.; Pepe, P.; La Vignera, S.; Improta, G.; Bosco, P.; Calogero, A. E.
In: European journal of histochemistry : EJH, Vol. 57, No. 2, 15.04.2013, p. 80-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue
AU - Salemi, Michele
AU - Galia, A.
AU - Fraggetta, F.
AU - La Corte, C.
AU - Pepe, P.
AU - La Vignera, S.
AU - Improta, G.
AU - Bosco, P.
AU - Calogero, A. E.
PY - 2013/4/15
Y1 - 2013/4/15
N2 - A genetic background has been implicated in the development of prostate cancer. Protein microarrays have enabled the identification of proteins, some of which associated with apoptosis, that may play a role in the development of such a tumor. Inhibition of apoptosis is a co-factor that contributes to the onset and progression of prostate cancer, though the molecular mechanisms are not entirely understood. Poly (ADP-ribose) polymerase 1 (PARP-1) gene is required for translocation of the apoptosis-inducing factor (AIF) from the mitochondria to the nucleus. Hence, it is involved in programmed cell death. Different PARP-1 gene expression has been observed in various tumors such as glioblastoma, lung, ovarian, endometrial, and skin cancers. We evaluated the expression of PARP-1 protein in prostatic cancer and normal prostate tissues by immunohistochemistry in 40 men with prostate cancer and in 37 normal men. Positive nuclear PARP-1 staining was found in all samples (normal prostate and prostate cancer tissues). No cytoplasmic staining was observed in any sample. PARP-1-positive cells resulted significantly higher in patients with prostate carcinoma compared with controls (P
AB - A genetic background has been implicated in the development of prostate cancer. Protein microarrays have enabled the identification of proteins, some of which associated with apoptosis, that may play a role in the development of such a tumor. Inhibition of apoptosis is a co-factor that contributes to the onset and progression of prostate cancer, though the molecular mechanisms are not entirely understood. Poly (ADP-ribose) polymerase 1 (PARP-1) gene is required for translocation of the apoptosis-inducing factor (AIF) from the mitochondria to the nucleus. Hence, it is involved in programmed cell death. Different PARP-1 gene expression has been observed in various tumors such as glioblastoma, lung, ovarian, endometrial, and skin cancers. We evaluated the expression of PARP-1 protein in prostatic cancer and normal prostate tissues by immunohistochemistry in 40 men with prostate cancer and in 37 normal men. Positive nuclear PARP-1 staining was found in all samples (normal prostate and prostate cancer tissues). No cytoplasmic staining was observed in any sample. PARP-1-positive cells resulted significantly higher in patients with prostate carcinoma compared with controls (P
KW - Immunoistochemistry
KW - PARP-1gene
KW - Prostate cancer
KW - Proteinexpression
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UR - http://www.scopus.com/inward/citedby.url?scp=84876486633&partnerID=8YFLogxK
U2 - 10.4081/ejh.2013.e13
DO - 10.4081/ejh.2013.e13
M3 - Article
VL - 57
SP - 80
EP - 82
JO - European Journal of Histochemistry
JF - European Journal of Histochemistry
SN - 1121-760X
IS - 2
ER -