Abstract
A skeletal dysplasia with previously unreported features is presented. Its evolution was characterized by growth abnormalities of bones without involvement of other organs. Advanced bone age, increased stature and irregular epiphyseal ossification with stippling of the main long bones were documented. Physeal overgrowth was massive in the left proximal humerus and femur. Furthermore, the hip joint appeared fused with an abundant mass of pathological calcific tissue extending from the femur to the ilium. Pathological epiphyses were characterized by anarchic cartilaginous proliferation with multiple ossification centres, while lamellar bone apposition and remodelling were normal. The observed bone changes were different from those in any previously reported syndrome, metabolic defect or bone dysplasia. However, they clearly indicated a defect of endochondral ossification with some resemblance to phenotypes observed in dysplasia epiphysealis hemimelica.
| Original language | English |
|---|---|
| Pages (from-to) | 1025-1030 |
| Number of pages | 6 |
| Journal | Pediatric Radiology |
| Volume | 37 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2007 |
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Keywords
- Epiphyseal growth
- Growth abnormalities
- Physeal overgrowth
- Skeletal dysplasia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Poly-epiphyseal overgrowth : Description of a previously unreported skeletal dysplasia. / Pazzaglia, Ugo E.; Beluffi, Giampiero; Marchi, Antonietta; Bozzola, Mauro; Savasta, Salvatore; Bonaspetti, Giovanni.
In: Pediatric Radiology, Vol. 37, No. 10, 10.2007, p. 1025-1030.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Poly-epiphyseal overgrowth
T2 - Description of a previously unreported skeletal dysplasia
AU - Pazzaglia, Ugo E.
AU - Beluffi, Giampiero
AU - Marchi, Antonietta
AU - Bozzola, Mauro
AU - Savasta, Salvatore
AU - Bonaspetti, Giovanni
PY - 2007/10
Y1 - 2007/10
N2 - A skeletal dysplasia with previously unreported features is presented. Its evolution was characterized by growth abnormalities of bones without involvement of other organs. Advanced bone age, increased stature and irregular epiphyseal ossification with stippling of the main long bones were documented. Physeal overgrowth was massive in the left proximal humerus and femur. Furthermore, the hip joint appeared fused with an abundant mass of pathological calcific tissue extending from the femur to the ilium. Pathological epiphyses were characterized by anarchic cartilaginous proliferation with multiple ossification centres, while lamellar bone apposition and remodelling were normal. The observed bone changes were different from those in any previously reported syndrome, metabolic defect or bone dysplasia. However, they clearly indicated a defect of endochondral ossification with some resemblance to phenotypes observed in dysplasia epiphysealis hemimelica.
AB - A skeletal dysplasia with previously unreported features is presented. Its evolution was characterized by growth abnormalities of bones without involvement of other organs. Advanced bone age, increased stature and irregular epiphyseal ossification with stippling of the main long bones were documented. Physeal overgrowth was massive in the left proximal humerus and femur. Furthermore, the hip joint appeared fused with an abundant mass of pathological calcific tissue extending from the femur to the ilium. Pathological epiphyses were characterized by anarchic cartilaginous proliferation with multiple ossification centres, while lamellar bone apposition and remodelling were normal. The observed bone changes were different from those in any previously reported syndrome, metabolic defect or bone dysplasia. However, they clearly indicated a defect of endochondral ossification with some resemblance to phenotypes observed in dysplasia epiphysealis hemimelica.
KW - Epiphyseal growth
KW - Growth abnormalities
KW - Physeal overgrowth
KW - Skeletal dysplasia
UR - http://www.scopus.com/inward/record.url?scp=34548762453&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548762453&partnerID=8YFLogxK
U2 - 10.1007/s00247-007-0532-z
DO - 10.1007/s00247-007-0532-z
M3 - Article
C2 - 17653707
AN - SCOPUS:34548762453
VL - 37
SP - 1025
EP - 1030
JO - Pediatric Radiology
JF - Pediatric Radiology
SN - 0301-0449
IS - 10
ER -