Poly-L-lactic acid β-tricalcium phosphate screws: A preliminary in vivo biocompatibility study

Nicola Magarelli, M. A. Savastano, D. Palmieri, R. Zappacosta, G. Lattanzio, V. Salini, C. A. Orso, G. Guglielmi, C. Colosimo

Research output: Contribution to journalArticlepeer-review


The aim of this study is to assess the biocompatibility of two types of Poly-L-lactic acid (PLLA) screws (with either hydroxiapatite (HA) or β-tricalcium phosphate (β-TCP)) implanted in the left femur of four sheep euthanized at 42, 50, 57 and 84 days after surgery. Titanium screws were also implanted for comparison purposes. No signs of inflammation were seen in the 240 specimens. A rating of "+/-"for macrophages and "-"for neutrophils was assigned to all specimens. All specimens were assigned a rating which ranged from "+/-" to "+++" for fibroblasts and osteoblasts. The presence of macrophages, neutrophils and fibroblasts/osteoblasts was not statistically different for the four implantation periods. PLLA implants with β-TCP have a biocompatibility comparable to PLLA implants with HA.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalInternational Journal of Immunopathology and Pharmacology
Issue number1
Publication statusPublished - Jan 2007


  • Biocompatibility
  • Biodegradable implants
  • Bone
  • Inflammation
  • Macrophages
  • Neutrophils

ASJC Scopus subject areas

  • Pharmacology

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