Polyamine biosynthetic decarboxylases in muscles of rats with different experimental myopathies

Erna C. Lorenzini, Bruno Colombo, Maria E. Ferioli, Giuseppe Scalabrino, Nicholas Canal

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The activities of the two polyamine biosynthetic decarboxylases (PBD), l-ornithine decarboxylase (ODC) and S-adenosyl-l-methionine decarboxylase (SAMD), have been measured in quadriceps femoris of rats killed at different times after the induction of calciphylaxis- or serotonin(5-HT)-induced myopathy. Decreases in both PBD levels were observed at early times after both myotoxic treatments. Subsequent progressive increases in both enzyme levels were observed to nearly control values by 4 days after 5-HT administration. In the 5-HT-treated rats, the effects on the myocardial PBD activities were different from those in skeletal muscle, with no effect on ODC but much on SAMD, when rats were killed shortly after 5-HT injection. These results demonstrate that the time-course of the changes in PBD activities in quadriceps femoris mirrors quite well the successive occurrence of degenerative and regenerative processes during the calciphylaxis-induced myopathy and the 5-HT-induced myopathy; it is 5-HT that is mainly responsible for the decreases in PBD levels observed in both experimental myopathies, since dihydrotachysterol alone was without any effect on PBD activity levels and 5-HT alone was effective; myocardial ODC reacts more slowly to 5-HT than quadriceps femoris ODC.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalJournal of the Neurological Sciences
Volume89
Issue number1
DOIs
Publication statusPublished - 1989

Fingerprint

Carboxy-Lyases
Polyamines
Muscular Diseases
Serotonin
Muscles
Ornithine Decarboxylase
Quadriceps Muscle
Calciphylaxis
Dihydrotachysterol
Skeletal Muscle
Injections

Keywords

  • Calciphylaxis
  • Myocardium
  • Ornithine decarboxylase
  • Quadriceps femoris
  • S-adenosyl-l-methionine decarboxylase
  • Serotonin myopathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Polyamine biosynthetic decarboxylases in muscles of rats with different experimental myopathies. / Lorenzini, Erna C.; Colombo, Bruno; Ferioli, Maria E.; Scalabrino, Giuseppe; Canal, Nicholas.

In: Journal of the Neurological Sciences, Vol. 89, No. 1, 1989, p. 27-35.

Research output: Contribution to journalArticle

Lorenzini, Erna C. ; Colombo, Bruno ; Ferioli, Maria E. ; Scalabrino, Giuseppe ; Canal, Nicholas. / Polyamine biosynthetic decarboxylases in muscles of rats with different experimental myopathies. In: Journal of the Neurological Sciences. 1989 ; Vol. 89, No. 1. pp. 27-35.
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