Polyamine levels and ODC activity in intestinal-type and diffuse-type gastric carcinoma

Francesco Russo, Michele Linsalata, Italo Giorgio, Maria Lucia Caruso, Raffaele Armentano, Alfredo Di Leo

Research output: Contribution to journalArticle

Abstract

Gastric carcinomas are divided into two types according to Lauren's classification: intestinal and diffuse types. Polyamines (putrescine, spermidine, and spermine) are polycations involved in neoplastic growth of gastrointestinal mucosa. A key role is also played by ornithine decarboxylase, the rate limiting enzyme in polyamine metabolism. Our aim was to investigate whether there were differences between the two types of tumor in polyamine metabolism. Twenty-seven patients with gastric carcinoma entered the study. Seventeen carcinomas were classified as diffuse type and 10 as intestinal type. Polyamine levels were evaluated by high-performance iquid chromatography. Ornithine decarboxylase activity was measured by a radiometric technique. Polyamine levels and ornithine decarboxylase activity were significantly higher in intestinal type samples than diffuse type samples. A similarity of polyamine levels in intestinal type samples with levels previously observed in patients with colorectal adenocarcinoma was also found. These findings show a different proliferative behavior of these two types of tumor, and therefore different therapeutic strategies can be hypothesized.

Original languageEnglish
Pages (from-to)576-579
Number of pages4
JournalDigestive Diseases and Sciences
Volume42
Issue number3
DOIs
Publication statusPublished - 1997

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Keywords

  • gastric carcinoma
  • Lauren's classification
  • ornithine decarboxylase
  • polyamines

ASJC Scopus subject areas

  • Gastroenterology

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