Polychemotherapy for early breast cancer: An overview of the randomised clinical trials with quality-adjusted survival analysis

Bernard F. Cole, Richard D. Gelber, Shari Gelber, Alan S. Coates, Aron Goldhirsch

Research output: Contribution to journalArticle

Abstract

Background: Overview analysis involving 18 000 women with breast cancer in 47 randomised trials showed that prolonged chemotherapy significantly reduces the risk of relapse and death compared with no chemotherapy. Here we express the size of the benefit in terms of quality-adjusted survival time gained. Methods: We used the Q-TWiST method (Quality-adjusted Time Without Symptoms of disease and Toxicity of treatment) to provide treatment comparisons within 10 years' follow-up, incorporating differences in quality of life associated with times patients spend with chemotherapy toxic effects, after relapse, and without symptoms of relapse or toxicity. Findings: Within 10 years' follow-up the benefit of increased relapse-free and overall survival for younger women (

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalLancet
Volume358
Issue number9278
DOIs
Publication statusPublished - Jul 28 2001

ASJC Scopus subject areas

  • Medicine(all)

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