Polychlorobiphenyl levels in the serum of cats from residential flats in Italy: Role of the indoor environment

Francesco Paolo Serpe, Filomena Fiorito, Mauro Esposito, Angelo Ferrari, Federico Fracassi, Roberto Miniero, Marco Pietra, Paola Roncada, Gianfranco Brambilla

Research output: Contribution to journalArticle

Abstract

The domestic cat (Felis catus) was used as a sentinel of exposure to polychlorobiphenyls (PCBs) in indoor urban environments y. Sera from 120 cats were pooled to form 30 different groups selected by age (<2 years; > 2 ≤ 8 years; > 8 years), sex, municipality (Bologna and Turin) and environment (indoor vs. outdoor). Test portions of 1 mL were analyzed by means of gas chromatography coupled to high-resolution mass spectrometry (GC-HRMS) for six selected indicators non-dioxin-like PCBs (∑6 PCBs: congeners #28, #52, #101, #132, #153 and #180) and the results were computed in the upper-bound mode. The internal dose of PCBs attributable to the cats' alimentary lipid intake ranged from 32.4 to 1,446 ng/g (P50 165; mean 258). The Wilcoxon test revealed significantly lower PCB burden in “outdoor” groups than in “indoor” groups. Age correlated well with the heptachlorinated and most bio-accumulative congener, PCB #180, and slightly with hexachlorinated PCBs #138 and #153. Contamination attributable to house dust collected in 15 living-rooms ranged from 10.0 to 279 ng/g dry weight (P50 97.4; mean 94.4). Exposure estimates indicated a 0.6–16 ng/kg bw range of daily ∑6 PCB intake from a default value of 200 mg/cat of dust ingestion. The intake of PCBs due to dust ingestion fell within the same order of magnitude as that computed from a 60 g daily intake of commercial dry pet foods, while inhalation accounted for 0.21–8.2 ng/kg bw/day, on setting the nominal ∑6 PCB contamination in outdoor and indoor air at 0.37 and 15 ng/m3, respectively. Italian indoor cats could be exposed to higher levels of ∑6 PCBs than the Reference Dose (RfD) of 10 ng/kg/bw/day; this supports the World Health Organization's statement that the quality of the indoor environment is a major determinant of health.

Original languageEnglish
Pages (from-to)777-785
Number of pages9
JournalJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
Volume53
Issue number9
DOIs
Publication statusPublished - Jul 29 2018

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Dust
Contamination
Health
Gas chromatography
Lipids
Mass spectrometry
Air

Keywords

  • Cats
  • exposure
  • house dust
  • indoor
  • polychlorobiphenyls
  • serum

ASJC Scopus subject areas

  • Environmental Engineering

Cite this

Polychlorobiphenyl levels in the serum of cats from residential flats in Italy : Role of the indoor environment. / Serpe, Francesco Paolo; Fiorito, Filomena; Esposito, Mauro; Ferrari, Angelo; Fracassi, Federico; Miniero, Roberto; Pietra, Marco; Roncada, Paola; Brambilla, Gianfranco.

In: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, Vol. 53, No. 9, 29.07.2018, p. 777-785.

Research output: Contribution to journalArticle

Serpe, Francesco Paolo ; Fiorito, Filomena ; Esposito, Mauro ; Ferrari, Angelo ; Fracassi, Federico ; Miniero, Roberto ; Pietra, Marco ; Roncada, Paola ; Brambilla, Gianfranco. / Polychlorobiphenyl levels in the serum of cats from residential flats in Italy : Role of the indoor environment. In: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering. 2018 ; Vol. 53, No. 9. pp. 777-785.
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