Polycomb group proteins in cell cycle progression and cancer

Diego Pasini, Adrian P. Bracken, Kristian Helin

Research output: Contribution to journalArticle

Abstract

Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalCell Cycle
Volume3
Issue number4
Publication statusPublished - Apr 2004

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Keywords

  • E2F
  • Epigenetics
  • EZH2
  • Histone methyl transferase
  • Polycomb group
  • PRC2

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Pasini, D., Bracken, A. P., & Helin, K. (2004). Polycomb group proteins in cell cycle progression and cancer. Cell Cycle, 3(4), 396-400.