Abstract
Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
| Original language | English |
|---|---|
| Pages (from-to) | 396-400 |
| Number of pages | 5 |
| Journal | Cell Cycle |
| Volume | 3 |
| Issue number | 4 |
| Publication status | Published - Apr 2004 |
Keywords
- E2F
- Epigenetics
- EZH2
- Histone methyl transferase
- Polycomb group
- PRC2
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology