Abstract
Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
Original language | English |
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Pages (from-to) | 396-400 |
Number of pages | 5 |
Journal | Cell Cycle |
Volume | 3 |
Issue number | 4 |
Publication status | Published - Apr 2004 |
Keywords
- E2F
- Epigenetics
- EZH2
- Histone methyl transferase
- Polycomb group
- PRC2
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology