Polycomb group proteins in cell cycle progression and cancer

Diego Pasini; Adrian P. Bracken; Kristian Helin

Polycomb group proteins in cell cycle progression and cancer

Diego Pasini, Adrian P. Bracken, Kristian Helin

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.

Original language	English
Pages (from-to)	396-400
Number of pages	5
Journal	Cell Cycle
Volume	3
Issue number	4
Publication status	Published - Apr 2004

Keywords

E2F
Epigenetics
EZH2
Histone methyl transferase
Polycomb group
PRC2

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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abstract = "Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.",

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KW - EZH2

KW - Histone methyl transferase

KW - Polycomb group

KW - PRC2

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Polycomb group proteins in cell cycle progression and cancer

Abstract

Keywords

ASJC Scopus subject areas

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Cite this