Abstract
Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
| Original language | English |
|---|---|
| Pages (from-to) | 396-400 |
| Number of pages | 5 |
| Journal | Cell Cycle |
| Volume | 3 |
| Issue number | 4 |
| Publication status | Published - Apr 2004 |
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Keywords
- E2F
- Epigenetics
- EZH2
- Histone methyl transferase
- Polycomb group
- PRC2
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Polycomb group proteins in cell cycle progression and cancer. / Pasini, Diego; Bracken, Adrian P.; Helin, Kristian.
In: Cell Cycle, Vol. 3, No. 4, 04.2004, p. 396-400.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polycomb group proteins in cell cycle progression and cancer
AU - Pasini, Diego
AU - Bracken, Adrian P.
AU - Helin, Kristian
PY - 2004/4
Y1 - 2004/4
N2 - Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
AB - Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
KW - E2F
KW - Epigenetics
KW - EZH2
KW - Histone methyl transferase
KW - Polycomb group
KW - PRC2
UR - http://www.scopus.com/inward/record.url?scp=3042702970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042702970&partnerID=8YFLogxK
M3 - Article
C2 - 14752272
AN - SCOPUS:3042702970
VL - 3
SP - 396
EP - 400
JO - Cell Cycle
JF - Cell Cycle
SN - 1538-4101
IS - 4
ER -