Polycomb proteins in mammalian cell differentiation and plasticity

Carolina Prezioso, Valerio Orlando

Research output: Contribution to journalArticle

Abstract

During development cell differentiation is accompanied by progressive restriction of the developmental potential and increased structural and functional specialization of cells. In this context, mechanisms of cell memory guarantee that cells maintain different identities previously determined by the integrated action of signalling and specific sets of transcription factors. Unraveling the molecular basis by which cells build and maintain their memory represents one of the most fascinating problems in biology. PcG proteins were originally identified as part of an epigenetic cellular memory system that controls gene silencing via chromatin structure. However, recent reports suggest that they are also involved in controlling dynamics and plasticity of gene regulation, particularly during differentiation, by interacting with other components of the transcriptional apparatus. In this review, we discuss the role of PcG proteins in pluripotent ES cells and in well known mammalian cell differentiation systems including skeletal muscle, epidermal, neuronal differentiation. The emerging picture suggests that indeed, plasticity and not rigidity is a fundamental aspect of PcG physiology and cell memory function.

Original languageEnglish
Pages (from-to)2067-2077
Number of pages11
JournalFEBS Letters
Volume585
Issue number13
DOIs
Publication statusPublished - Jul 7 2011

Keywords

  • Cell differentiation
  • Cell memory
  • Chromatin
  • Epigenetics
  • PcG proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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