Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy

Teresa Infante, Francesco P. Mancini, Alessandro Lanza, Andrea Soricelli, Filomena de Nigris, Claudio Napoli

Research output: Contribution to journalArticlepeer-review

Abstract

Yin Yang 1 (YY1) is a member of polycomb protein family involved in epigenetic modifications and transcriptional controls. We have shown that YY1 acts as positive regulator of tumor growth and angiogenesis by interfering with the VEGFA network. Yet, the link between polycomb chromatin complex and hypoxia regulation of VEGFA is still poorly understood. Here, we establish that hypoxia impairs YY1 binding to VEGFA mRNA 3'UTR (p.

Original languageEnglish
Pages (from-to)975-986
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1853
Issue number5
DOIs
Publication statusPublished - May 1 2015

Keywords

  • Angiogenesis
  • Epigenetic
  • Hypoxia
  • MiRNA
  • VEGFa
  • YY1

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy'. Together they form a unique fingerprint.

Cite this