Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy

Teresa Infante; Francesco P. Mancini; Alessandro Lanza; Andrea Soricelli; Filomena de Nigris; Claudio Napoli

doi:10.1016/j.bbamcr.2015.01.009

Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy

Teresa Infante, Francesco P. Mancini, Alessandro Lanza, Andrea Soricelli, Filomena de Nigris, Claudio Napoli

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Abstract

Yin Yang 1 (YY1) is a member of polycomb protein family involved in epigenetic modifications and transcriptional controls. We have shown that YY1 acts as positive regulator of tumor growth and angiogenesis by interfering with the VEGFA network. Yet, the link between polycomb chromatin complex and hypoxia regulation of VEGFA is still poorly understood. Here, we establish that hypoxia impairs YY1 binding to VEGFA mRNA 3'UTR (p.

Original language	English
Pages (from-to)	975-986
Number of pages	12
Journal	Biochimica et Biophysica Acta - Molecular Cell Research
Volume	1853
Issue number	5
DOIs	https://doi.org/10.1016/j.bbamcr.2015.01.009
Publication status	Published - May 1 2015

Keywords

Angiogenesis
Epigenetic
Hypoxia
MiRNA
VEGFa
YY1

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Medicine(all)

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10.1016/j.bbamcr.2015.01.009

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title = "Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy",

abstract = "Yin Yang 1 (YY1) is a member of polycomb protein family involved in epigenetic modifications and transcriptional controls. We have shown that YY1 acts as positive regulator of tumor growth and angiogenesis by interfering with the VEGFA network. Yet, the link between polycomb chromatin complex and hypoxia regulation of VEGFA is still poorly understood. Here, we establish that hypoxia impairs YY1 binding to VEGFA mRNA 3'UTR (p. ",

keywords = "Angiogenesis, Epigenetic, Hypoxia, MiRNA, VEGFa, YY1",

author = "Teresa Infante and Mancini, {Francesco P.} and Alessandro Lanza and Andrea Soricelli and {de Nigris}, Filomena and Claudio Napoli",

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AU - Infante, Teresa

AU - Mancini, Francesco P.

AU - Lanza, Alessandro

AU - Soricelli, Andrea

AU - de Nigris, Filomena

AU - Napoli, Claudio

PY - 2015/5/1

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N2 - Yin Yang 1 (YY1) is a member of polycomb protein family involved in epigenetic modifications and transcriptional controls. We have shown that YY1 acts as positive regulator of tumor growth and angiogenesis by interfering with the VEGFA network. Yet, the link between polycomb chromatin complex and hypoxia regulation of VEGFA is still poorly understood. Here, we establish that hypoxia impairs YY1 binding to VEGFA mRNA 3'UTR (p.

AB - Yin Yang 1 (YY1) is a member of polycomb protein family involved in epigenetic modifications and transcriptional controls. We have shown that YY1 acts as positive regulator of tumor growth and angiogenesis by interfering with the VEGFA network. Yet, the link between polycomb chromatin complex and hypoxia regulation of VEGFA is still poorly understood. Here, we establish that hypoxia impairs YY1 binding to VEGFA mRNA 3'UTR (p.

KW - Angiogenesis

KW - Epigenetic

KW - Hypoxia

KW - MiRNA

KW - VEGFa

KW - YY1

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Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy

Abstract

Keywords

ASJC Scopus subject areas

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