Yin Yang 1 (YY1) is a member of polycomb protein family involved in epigenetic modifications and transcriptional controls. We have shown that YY1 acts as positive regulator of tumor growth and angiogenesis by interfering with the VEGFA network. Yet, the link between polycomb chromatin complex and hypoxia regulation of VEGFA is still poorly understood. Here, we establish that hypoxia impairs YY1 binding to VEGFA mRNA 3'UTR (p.
|Number of pages||12|
|Journal||Biochimica et Biophysica Acta - Molecular Cell Research|
|Publication status||Published - May 1 2015|
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology