Polycythemia vera treated with recombinant interferon-alpha 2a: Evidence of a selective effect on the malignant clone

Paolo Massaro, Paolo Foa, Mauro Pomati, Maria Luisa LaTargia, Alessandra Iurlo, Claudia Clerici, Sarah Caldiera, Monica Fornier, Anna Teresa Maiolo

Research output: Contribution to journalArticle

Abstract

We periodically analyzed bone-marrow cytogenetic features in 8 patients belonging to a series of 38 subjects with polycythemia vera (PV), all treated with recombinant interferon-alpha 2a (rIFN-alpha) at a weekly dose of 9,000,000 IU. Six out of these 8 patients never showed any chromosome alterations, while 2 displayed at diagnosis the presence of trisomy 8 in all bone-marrow metaphases. Interestingly enough, in these 2 patients rIFN-alpha treatment was able to induce not only complete hematological response but also the disappearance of trisomy 8, as shown by conventional cytogenetic investigation and fluorescence in situ hybridization performed on bone- marrow cells after I year of treatment. This finding indicates that, as previously shown in chronic myeloid leukemia, in PV rIFN-alpha can also eradicate the malignant clone by means of a selective effect on bone-marrow transformed cells.

Original languageEnglish
Pages (from-to)126-128
Number of pages3
JournalAmerican Journal of Hematology
Volume56
Issue number2
DOIs
Publication statusPublished - Oct 1997

Fingerprint

Polycythemia Vera
Clone Cells
Cytogenetics
Bone Marrow Cells
Bone Marrow
Metaphase
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Fluorescence In Situ Hybridization
Chromosomes
Therapeutics
interferon alfa-2a
Trisomy Chromosome 8

Keywords

  • Cytogenetics
  • Fluorescence in situ hybridization
  • Interferon-alpha
  • Polycythemia vera

ASJC Scopus subject areas

  • Hematology

Cite this

Polycythemia vera treated with recombinant interferon-alpha 2a : Evidence of a selective effect on the malignant clone. / Massaro, Paolo; Foa, Paolo; Pomati, Mauro; LaTargia, Maria Luisa; Iurlo, Alessandra; Clerici, Claudia; Caldiera, Sarah; Fornier, Monica; Maiolo, Anna Teresa.

In: American Journal of Hematology, Vol. 56, No. 2, 10.1997, p. 126-128.

Research output: Contribution to journalArticle

Massaro, Paolo ; Foa, Paolo ; Pomati, Mauro ; LaTargia, Maria Luisa ; Iurlo, Alessandra ; Clerici, Claudia ; Caldiera, Sarah ; Fornier, Monica ; Maiolo, Anna Teresa. / Polycythemia vera treated with recombinant interferon-alpha 2a : Evidence of a selective effect on the malignant clone. In: American Journal of Hematology. 1997 ; Vol. 56, No. 2. pp. 126-128.
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