Polyethylenimine in medicinal chemistry

Paola Vicennati, Antonella Giuliano, Giancarlo Ortaggi, Andrea Masotti

Research output: Contribution to journalArticlepeer-review


Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.

Original languageEnglish
Pages (from-to)2826-2839
Number of pages14
JournalCurrent Medicinal Chemistry
Issue number27
Publication statusPublished - Nov 2008


  • Biomedical applications
  • DNA
  • Drug delivery
  • Gene therapy
  • Medicinal chemistry
  • Polyethylenimine
  • Polymer
  • Transfection

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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