Polygraphic respiratory events during sleep with noninvasive ventilation in children: Description, prevalence, and clinical consequences

Valeria Caldarelli, Jean Christian Borel, Sonia Khirani, Adriana Ramirez, Renato Cutrera, Jean Louis Pépin, Brigitte Fauroux

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The optimal monitoring during sleep with noninvasive positive pressure ventilation (NPPV) has not been validated in children. The aim of the study was to describe on polygraphic (PG) recordings the respiratory events and associated autonomic arousals (AA) and/or 3 % desaturations (DS3%) during nocturnal NPPV. Methods: This was a prospective descriptive study performed in the pulmonology unit of a pediatric university hospital. Consecutive patients admitted for routine follow-up of long-term NPPV were enrolled. Nocturnal PG during sleep with NPPV was performed. A second PG was performed after adjustment of the ventilatory settings when a respiratory event occurred more than 50 times/h. Results: The PG tracings of 39 patients (age range 1-18 years) were analyzed. Underlying diagnoses included neuromuscular disease (n = 13), obstructive sleep apnea (n = 15), and lung disease (n = 11). Unintentional leaks, patient-ventilator asynchronies, decrease in ventilatory drive, upper airway obstruction with or without reduction of ventilatory drive, and mixed events were observed in 27, 33, 10, 11, 12, and 3 % of the patients, respectively. A predominant respiratory event was observed in all patients. The mean duration spent with respiratory events was 32 ± 30 % (range 3-96 %) of total recording time. Unintentional leaks were the most frequently associated with AA, whereas patient-ventilator asynchronies were rarely associated with AA or DS3%. In eight re-evaluated patients, a decrease in the main event was observed (p = 0.005). Conclusion: Respiratory events during sleep with NPPV are common in children treated with long-term NPPV. Consequences of respiratory events vary according to the type of event with unintentional leaks being associated preferentially with AA.

Original languageEnglish
Pages (from-to)739-746
Number of pages8
JournalIntensive Care Medicine
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Noninvasive Ventilation
Positive-Pressure Respiration
Sleep
Arousal
Mechanical Ventilators
Social Adjustment
Pulmonary Medicine
Neuromuscular Diseases
Pediatric Hospitals
Polysomnography
Obstructive Sleep Apnea
Airway Obstruction
Lung Diseases
Prospective Studies

Keywords

  • Arousal
  • Desaturation
  • Noninvasive positive pressure ventilation
  • Patient-ventilator asynchrony
  • Polygraphy
  • Sleep

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Polygraphic respiratory events during sleep with noninvasive ventilation in children : Description, prevalence, and clinical consequences. / Caldarelli, Valeria; Borel, Jean Christian; Khirani, Sonia; Ramirez, Adriana; Cutrera, Renato; Pépin, Jean Louis; Fauroux, Brigitte.

In: Intensive Care Medicine, Vol. 39, No. 4, 04.2013, p. 739-746.

Research output: Contribution to journalArticle

Caldarelli, Valeria ; Borel, Jean Christian ; Khirani, Sonia ; Ramirez, Adriana ; Cutrera, Renato ; Pépin, Jean Louis ; Fauroux, Brigitte. / Polygraphic respiratory events during sleep with noninvasive ventilation in children : Description, prevalence, and clinical consequences. In: Intensive Care Medicine. 2013 ; Vol. 39, No. 4. pp. 739-746.
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abstract = "Purpose: The optimal monitoring during sleep with noninvasive positive pressure ventilation (NPPV) has not been validated in children. The aim of the study was to describe on polygraphic (PG) recordings the respiratory events and associated autonomic arousals (AA) and/or 3 {\%} desaturations (DS3{\%}) during nocturnal NPPV. Methods: This was a prospective descriptive study performed in the pulmonology unit of a pediatric university hospital. Consecutive patients admitted for routine follow-up of long-term NPPV were enrolled. Nocturnal PG during sleep with NPPV was performed. A second PG was performed after adjustment of the ventilatory settings when a respiratory event occurred more than 50 times/h. Results: The PG tracings of 39 patients (age range 1-18 years) were analyzed. Underlying diagnoses included neuromuscular disease (n = 13), obstructive sleep apnea (n = 15), and lung disease (n = 11). Unintentional leaks, patient-ventilator asynchronies, decrease in ventilatory drive, upper airway obstruction with or without reduction of ventilatory drive, and mixed events were observed in 27, 33, 10, 11, 12, and 3 {\%} of the patients, respectively. A predominant respiratory event was observed in all patients. The mean duration spent with respiratory events was 32 ± 30 {\%} (range 3-96 {\%}) of total recording time. Unintentional leaks were the most frequently associated with AA, whereas patient-ventilator asynchronies were rarely associated with AA or DS3{\%}. In eight re-evaluated patients, a decrease in the main event was observed (p = 0.005). Conclusion: Respiratory events during sleep with NPPV are common in children treated with long-term NPPV. Consequences of respiratory events vary according to the type of event with unintentional leaks being associated preferentially with AA.",
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T1 - Polygraphic respiratory events during sleep with noninvasive ventilation in children

T2 - Description, prevalence, and clinical consequences

AU - Caldarelli, Valeria

AU - Borel, Jean Christian

AU - Khirani, Sonia

AU - Ramirez, Adriana

AU - Cutrera, Renato

AU - Pépin, Jean Louis

AU - Fauroux, Brigitte

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N2 - Purpose: The optimal monitoring during sleep with noninvasive positive pressure ventilation (NPPV) has not been validated in children. The aim of the study was to describe on polygraphic (PG) recordings the respiratory events and associated autonomic arousals (AA) and/or 3 % desaturations (DS3%) during nocturnal NPPV. Methods: This was a prospective descriptive study performed in the pulmonology unit of a pediatric university hospital. Consecutive patients admitted for routine follow-up of long-term NPPV were enrolled. Nocturnal PG during sleep with NPPV was performed. A second PG was performed after adjustment of the ventilatory settings when a respiratory event occurred more than 50 times/h. Results: The PG tracings of 39 patients (age range 1-18 years) were analyzed. Underlying diagnoses included neuromuscular disease (n = 13), obstructive sleep apnea (n = 15), and lung disease (n = 11). Unintentional leaks, patient-ventilator asynchronies, decrease in ventilatory drive, upper airway obstruction with or without reduction of ventilatory drive, and mixed events were observed in 27, 33, 10, 11, 12, and 3 % of the patients, respectively. A predominant respiratory event was observed in all patients. The mean duration spent with respiratory events was 32 ± 30 % (range 3-96 %) of total recording time. Unintentional leaks were the most frequently associated with AA, whereas patient-ventilator asynchronies were rarely associated with AA or DS3%. In eight re-evaluated patients, a decrease in the main event was observed (p = 0.005). Conclusion: Respiratory events during sleep with NPPV are common in children treated with long-term NPPV. Consequences of respiratory events vary according to the type of event with unintentional leaks being associated preferentially with AA.

AB - Purpose: The optimal monitoring during sleep with noninvasive positive pressure ventilation (NPPV) has not been validated in children. The aim of the study was to describe on polygraphic (PG) recordings the respiratory events and associated autonomic arousals (AA) and/or 3 % desaturations (DS3%) during nocturnal NPPV. Methods: This was a prospective descriptive study performed in the pulmonology unit of a pediatric university hospital. Consecutive patients admitted for routine follow-up of long-term NPPV were enrolled. Nocturnal PG during sleep with NPPV was performed. A second PG was performed after adjustment of the ventilatory settings when a respiratory event occurred more than 50 times/h. Results: The PG tracings of 39 patients (age range 1-18 years) were analyzed. Underlying diagnoses included neuromuscular disease (n = 13), obstructive sleep apnea (n = 15), and lung disease (n = 11). Unintentional leaks, patient-ventilator asynchronies, decrease in ventilatory drive, upper airway obstruction with or without reduction of ventilatory drive, and mixed events were observed in 27, 33, 10, 11, 12, and 3 % of the patients, respectively. A predominant respiratory event was observed in all patients. The mean duration spent with respiratory events was 32 ± 30 % (range 3-96 %) of total recording time. Unintentional leaks were the most frequently associated with AA, whereas patient-ventilator asynchronies were rarely associated with AA or DS3%. In eight re-evaluated patients, a decrease in the main event was observed (p = 0.005). Conclusion: Respiratory events during sleep with NPPV are common in children treated with long-term NPPV. Consequences of respiratory events vary according to the type of event with unintentional leaks being associated preferentially with AA.

KW - Arousal

KW - Desaturation

KW - Noninvasive positive pressure ventilation

KW - Patient-ventilator asynchrony

KW - Polygraphy

KW - Sleep

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