Polylactide-polyglycolide resorbable plates stimulates adipose tissue-derived stem cells towards osteoblasts differentiation

V. Sollazzo, A. Lucchese, A. Palmieri, I. Zollino, C. Iaccarino, G. Carnevali, F. Pezzetti, G. Brunelli, Francesco Carinci

Research output: Contribution to journalArticlepeer-review


Polylactide, polyglycolide materials or devices have been utilized routinely during maxillofacial, craniofacial, and orthopaedic reconstructive surgical procedures.(1) These materials combine the benefits of rigid fixation with the advantages of biodegradation, avoiding the need for implant removal and minimizing the risk of other complications.(2) To study how polylactide, polyglycolide acids plates (PLPG plates) can induce osteoblast differentiation and proliferation in mesenchymal stem cells, the expression levels of bone related genes (RUNX2, SP7, ALPL, SPP1, COL1A1, COL3A1 and FOSL1) and mesenchymal stem cells marker (ENG) were measured in adipose derived stem cells (ADSCs) and normal osteoblast (NO) cultivated on PLPG plates after 15 and 30 days of treatment using real time Reverse Transcription-Polymerase Chain Reaction. Significantly differentially expressed genes among ADSCs and NO were SP7, ENG, FOSL1, RUNX, ALPL and SPP1 in the irst 15 days of treatment and SP7, ENG FOSL1, COL3A1 COL1A1, SPP1 and ALPL after 30 days. The present study demonstrated that PLPG plates strongly influences the behavior of ADSCs in vitro by enhancing proliferation, differentiation and deposition of matrix.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Issue number2 SUPPL. 1
Publication statusPublished - 2011


  • Differentiation
  • Gene expression
  • Polyglycolide
  • Polylactide
  • Resorbable plates
  • Stem cells

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy


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