Polymorphic MAO-A and 5-HT-transporter genes: Analysis of interactions in panic disorder

Philipp Sand, Klaus Peter Lesch, Marco Catalano, Monica Bosi, Yana V. Syagailo, Olga Okladnova, Daniela Di Bella, Piermario Maffei, Armin Heils, Friedrich Friess, Ernestina Politi, Markus M. Nöthen, Petra Franke, Gerald Stöber, Jürgen Fritze, Wolfgang Maier, Peter Propping, Helmut Beckmann, Laura Bellodi, Peter RiedererJürgen Deckert

Research output: Contribution to journalArticlepeer-review

Abstract

Recurrent panic attacks, anticipatory anxiety and phobic avoidance characterise panic disorder. The influence of genetic factors on liability to the disease has been the object of several linkage and association studies and appears to relate to an oligo-or polygenic rather than a monogenic mode of inheritance. Recently, an excess of high activity monoamine oxidase A (MAO-A) gene promoter alleles was found in female patients with panic disorder. An analysis of possible synergistic effects of the MAO-A gene promoter variant and the short serotonin transporter (5-HTT) gene promoter variant in panic disorder was performed in a German and an Italian sample (combined panic disorder n = 144, combined controls n = 175). There was no significant difference in odds ratios, suggesting that the observed increase of genetic liability by the long MAO-A gene promoter allele is not modified by the 5-HTT gene promoter polymorphism.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalWorld Journal of Biological Psychiatry
Volume1
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • monoaminooxidase-A
  • panic disorder
  • promoter polymorphisms
  • serotonin transporter

ASJC Scopus subject areas

  • Biological Psychiatry
  • Psychiatry and Mental health

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