Polymorphic monoamine oxidase a and 5-HT-transporter genes: Analysis of interactions with panic disorder

P. Sand, K. P. Lesch, M. Catalano, M. Bosi, Y. Syagailo, P. Okladnova, D. DiBella, P. Maffei, M. M. Nöthen, P. Franke, G. Stöber, J. Fritze, W. Maier, P. Propping, H. Beckmann, L. Bellodi, P. Riederer, J. Deckert

Research output: Contribution to journalArticlepeer-review

Abstract

An excess of higher active, long MAO-A promoter alleles was described in women with panic disorder (Deckert et al., Human Molecular Genetics 8:621-624, 1999). For the less-active, short allele of a 5-HT-transporter promoter polymorphism an association with anxiety-related personality traits has been reported (Lesch et al., Science 274:1527-1531, 1996). We performed an analysis of possible synergistic effects in a German and an Italian sample (combined n=144, panic disorder and n=175, control). The described excess of higher active, long MAO-A promoter alleles among women with panic disorder was also found in this subsample of the original sample (p=0.02, Chi Square analysis). This effect was not modified by the different 5-HT-transporter promoter alleles. Only in men, a non-significant increase of the odds ratio by a factor of 2 in the presence of both the long MAO-A and 5-HT-transporter promoter alleles was observed (p=0.45). The statistical power even of the combined samples, however, was too small to detect an effect of this size with a significance level of p=0.05. As the contribution of individual genes to the pathogenesis of panic disorder is small, larger samples and wider collaborations will be necessary.

Original languageEnglish
Pages (from-to)558
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number4
Publication statusPublished - Aug 7 2000

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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