Abstract
An excess of higher active, long MAO-A promoter alleles was described in women with panic disorder (Deckert et al., Human Molecular Genetics 8:621-624, 1999). For the less-active, short allele of a 5-HT-transporter promoter polymorphism an association with anxiety-related personality traits has been reported (Lesch et al., Science 274:1527-1531, 1996). We performed an analysis of possible synergistic effects in a German and an Italian sample (combined n=144, panic disorder and n=175, control). The described excess of higher active, long MAO-A promoter alleles among women with panic disorder was also found in this subsample of the original sample (p=0.02, Chi Square analysis). This effect was not modified by the different 5-HT-transporter promoter alleles. Only in men, a non-significant increase of the odds ratio by a factor of 2 in the presence of both the long MAO-A and 5-HT-transporter promoter alleles was observed (p=0.45). The statistical power even of the combined samples, however, was too small to detect an effect of this size with a significance level of p=0.05. As the contribution of individual genes to the pathogenesis of panic disorder is small, larger samples and wider collaborations will be necessary.
| Original language | English |
|---|---|
| Pages (from-to) | 558 |
| Number of pages | 1 |
| Journal | American Journal of Medical Genetics - Neuropsychiatric Genetics |
| Volume | 96 |
| Issue number | 4 |
| Publication status | Published - Aug 7 2000 |
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ASJC Scopus subject areas
- Genetics(clinical)
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
Cite this
Polymorphic monoamine oxidase a and 5-HT-transporter genes : Analysis of interactions with panic disorder. / Sand, P.; Lesch, K. P.; Catalano, M.; Bosi, M.; Syagailo, Y.; Okladnova, P.; DiBella, D.; Maffei, P.; Nöthen, M. M.; Franke, P.; Stöber, G.; Fritze, J.; Maier, W.; Propping, P.; Beckmann, H.; Bellodi, L.; Riederer, P.; Deckert, J.
In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 96, No. 4, 07.08.2000, p. 558.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polymorphic monoamine oxidase a and 5-HT-transporter genes
T2 - Analysis of interactions with panic disorder
AU - Sand, P.
AU - Lesch, K. P.
AU - Catalano, M.
AU - Bosi, M.
AU - Syagailo, Y.
AU - Okladnova, P.
AU - DiBella, D.
AU - Maffei, P.
AU - Nöthen, M. M.
AU - Franke, P.
AU - Stöber, G.
AU - Fritze, J.
AU - Maier, W.
AU - Propping, P.
AU - Beckmann, H.
AU - Bellodi, L.
AU - Riederer, P.
AU - Deckert, J.
PY - 2000/8/7
Y1 - 2000/8/7
N2 - An excess of higher active, long MAO-A promoter alleles was described in women with panic disorder (Deckert et al., Human Molecular Genetics 8:621-624, 1999). For the less-active, short allele of a 5-HT-transporter promoter polymorphism an association with anxiety-related personality traits has been reported (Lesch et al., Science 274:1527-1531, 1996). We performed an analysis of possible synergistic effects in a German and an Italian sample (combined n=144, panic disorder and n=175, control). The described excess of higher active, long MAO-A promoter alleles among women with panic disorder was also found in this subsample of the original sample (p=0.02, Chi Square analysis). This effect was not modified by the different 5-HT-transporter promoter alleles. Only in men, a non-significant increase of the odds ratio by a factor of 2 in the presence of both the long MAO-A and 5-HT-transporter promoter alleles was observed (p=0.45). The statistical power even of the combined samples, however, was too small to detect an effect of this size with a significance level of p=0.05. As the contribution of individual genes to the pathogenesis of panic disorder is small, larger samples and wider collaborations will be necessary.
AB - An excess of higher active, long MAO-A promoter alleles was described in women with panic disorder (Deckert et al., Human Molecular Genetics 8:621-624, 1999). For the less-active, short allele of a 5-HT-transporter promoter polymorphism an association with anxiety-related personality traits has been reported (Lesch et al., Science 274:1527-1531, 1996). We performed an analysis of possible synergistic effects in a German and an Italian sample (combined n=144, panic disorder and n=175, control). The described excess of higher active, long MAO-A promoter alleles among women with panic disorder was also found in this subsample of the original sample (p=0.02, Chi Square analysis). This effect was not modified by the different 5-HT-transporter promoter alleles. Only in men, a non-significant increase of the odds ratio by a factor of 2 in the presence of both the long MAO-A and 5-HT-transporter promoter alleles was observed (p=0.45). The statistical power even of the combined samples, however, was too small to detect an effect of this size with a significance level of p=0.05. As the contribution of individual genes to the pathogenesis of panic disorder is small, larger samples and wider collaborations will be necessary.
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M3 - Article
AN - SCOPUS:33749106554
VL - 96
SP - 558
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 4
ER -