Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia

Davide Seripa, Maria Giovanna Matera, Grazia D'Onofrio, Daniele Sancarlo, Alessandra Bizzarro, Leandro Cascavilla, Francesco Paris, Carolina Gravina, Loriana Bonghi, Cristiano Capurso, Vincenzo Solfrizzi, Antonio Daniele, Carlo Masullo, Francesco Panza, Alberto Pilotto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Genotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD). Aims: To evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD. Methods: The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients. Results: No important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made. Conclusion: Our findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.

Original languageEnglish
Pages (from-to)424-431
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Volume29
Issue number5
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Vascular Dementia
Depression
Obsessive-Compulsive Disorder
Genotype
Haplotypes
Genes
Anxiety
Neurotransmitter Transport Proteins
Independent Living
Genetic Promoter Regions
Neuroimaging
Geriatrics
Documentation
Dementia
Serotonin
Healthy Volunteers

Keywords

  • 5-Hydroxytryptamine
  • 5-Hydroxytryptamine transporter
  • 5-Hydroxytryptamine transporter gene-linked polymorphic region
  • Polymorphism C
  • Solute carrier family 6 (neurotransmitter transporter, serotonin) member 4
  • Vascular dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience

Cite this

Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia. / Seripa, Davide; Matera, Maria Giovanna; D'Onofrio, Grazia; Sancarlo, Daniele; Bizzarro, Alessandra; Cascavilla, Leandro; Paris, Francesco; Gravina, Carolina; Bonghi, Loriana; Capurso, Cristiano; Solfrizzi, Vincenzo; Daniele, Antonio; Masullo, Carlo; Panza, Francesco; Pilotto, Alberto.

In: Dementia and Geriatric Cognitive Disorders, Vol. 29, No. 5, 06.2010, p. 424-431.

Research output: Contribution to journalArticle

Seripa, D, Matera, MG, D'Onofrio, G, Sancarlo, D, Bizzarro, A, Cascavilla, L, Paris, F, Gravina, C, Bonghi, L, Capurso, C, Solfrizzi, V, Daniele, A, Masullo, C, Panza, F & Pilotto, A 2010, 'Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia', Dementia and Geriatric Cognitive Disorders, vol. 29, no. 5, pp. 424-431. https://doi.org/10.1159/000275670
Seripa, Davide ; Matera, Maria Giovanna ; D'Onofrio, Grazia ; Sancarlo, Daniele ; Bizzarro, Alessandra ; Cascavilla, Leandro ; Paris, Francesco ; Gravina, Carolina ; Bonghi, Loriana ; Capurso, Cristiano ; Solfrizzi, Vincenzo ; Daniele, Antonio ; Masullo, Carlo ; Panza, Francesco ; Pilotto, Alberto. / Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia. In: Dementia and Geriatric Cognitive Disorders. 2010 ; Vol. 29, No. 5. pp. 424-431.
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abstract = "Background: Genotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD). Aims: To evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD. Methods: The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients. Results: No important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made. Conclusion: Our findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.",
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AU - Seripa, Davide

AU - Matera, Maria Giovanna

AU - D'Onofrio, Grazia

AU - Sancarlo, Daniele

AU - Bizzarro, Alessandra

AU - Cascavilla, Leandro

AU - Paris, Francesco

AU - Gravina, Carolina

AU - Bonghi, Loriana

AU - Capurso, Cristiano

AU - Solfrizzi, Vincenzo

AU - Daniele, Antonio

AU - Masullo, Carlo

AU - Panza, Francesco

AU - Pilotto, Alberto

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AB - Background: Genotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD). Aims: To evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD. Methods: The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients. Results: No important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made. Conclusion: Our findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.

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