Abstract
Background: Genotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD). Aims: To evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD. Methods: The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients. Results: No important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made. Conclusion: Our findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.
| Original language | English |
|---|---|
| Pages (from-to) | 424-431 |
| Number of pages | 8 |
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jun 2010 |
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Keywords
- 5-Hydroxytryptamine
- 5-Hydroxytryptamine transporter
- 5-Hydroxytryptamine transporter gene-linked polymorphic region
- Polymorphism C
- Solute carrier family 6 (neurotransmitter transporter, serotonin) member 4
- Vascular dementia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Cognitive Neuroscience
Cite this
Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia. / Seripa, Davide; Matera, Maria Giovanna; D'Onofrio, Grazia; Sancarlo, Daniele; Bizzarro, Alessandra; Cascavilla, Leandro; Paris, Francesco; Gravina, Carolina; Bonghi, Loriana; Capurso, Cristiano; Solfrizzi, Vincenzo; Daniele, Antonio; Masullo, Carlo; Panza, Francesco; Pilotto, Alberto.
In: Dementia and Geriatric Cognitive Disorders, Vol. 29, No. 5, 06.2010, p. 424-431.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia
AU - Seripa, Davide
AU - Matera, Maria Giovanna
AU - D'Onofrio, Grazia
AU - Sancarlo, Daniele
AU - Bizzarro, Alessandra
AU - Cascavilla, Leandro
AU - Paris, Francesco
AU - Gravina, Carolina
AU - Bonghi, Loriana
AU - Capurso, Cristiano
AU - Solfrizzi, Vincenzo
AU - Daniele, Antonio
AU - Masullo, Carlo
AU - Panza, Francesco
AU - Pilotto, Alberto
PY - 2010/6
Y1 - 2010/6
N2 - Background: Genotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD). Aims: To evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD. Methods: The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients. Results: No important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made. Conclusion: Our findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.
AB - Background: Genotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD). Aims: To evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD. Methods: The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients. Results: No important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made. Conclusion: Our findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.
KW - 5-Hydroxytryptamine
KW - 5-Hydroxytryptamine transporter
KW - 5-Hydroxytryptamine transporter gene-linked polymorphic region
KW - Polymorphism C
KW - Solute carrier family 6 (neurotransmitter transporter, serotonin) member 4
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=77952505261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952505261&partnerID=8YFLogxK
U2 - 10.1159/000275670
DO - 10.1159/000275670
M3 - Article
C2 - 20502016
AN - SCOPUS:77952505261
VL - 29
SP - 424
EP - 431
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 5
ER -