TY - JOUR
T1 - Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease
AU - Seripa, Davide
AU - Franceschi, Marilisa
AU - D'Onofrio, Grazia
AU - Panza, Francesco
AU - Cascavilla, Leandro
AU - Paris, Francesco
AU - Placentino, Giuliana
AU - Matera, Maria Giovanna
AU - Solfrizzi, Vincenzo
AU - Pilotto, Alberto
PY - 2008/6/27
Y1 - 2008/6/27
N2 - The promoter region of the serotonin transporter gene (SLC6A4) shows a 22-bp tandem repeat polymorphism, indicated as polymorphism C, that has been associated to depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding its association with Alzheimer's disease (AD). No data were reported regarding its association with questionable dementia (QD). In this study we investigate for polymorphism C in the SLC6A4 gene 302 elderly subjects with a clinical diagnosis of AD (n = 105), QD (n = 88) and no cognitive impairment (n = 114) attending a geriatric ward. A community-dwelling sample of 390 healthy subjects was also included in the analysis. A significant higher prevalence of the C16/C16 genotype in AD than in QD was observed (37.14% vs. 3%; p = 0.041, OR 2.001, 95%CI 1.018-4.024), while no differences in the C16/C14 and C14/C14 genotypes as well as in the estimated allele frequencies were found. No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD.
AB - The promoter region of the serotonin transporter gene (SLC6A4) shows a 22-bp tandem repeat polymorphism, indicated as polymorphism C, that has been associated to depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding its association with Alzheimer's disease (AD). No data were reported regarding its association with questionable dementia (QD). In this study we investigate for polymorphism C in the SLC6A4 gene 302 elderly subjects with a clinical diagnosis of AD (n = 105), QD (n = 88) and no cognitive impairment (n = 114) attending a geriatric ward. A community-dwelling sample of 390 healthy subjects was also included in the analysis. A significant higher prevalence of the C16/C16 genotype in AD than in QD was observed (37.14% vs. 3%; p = 0.041, OR 2.001, 95%CI 1.018-4.024), while no differences in the C16/C14 and C14/C14 genotypes as well as in the estimated allele frequencies were found. No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD.
KW - 5-Hydroxytriptamine (5HT)
KW - 5-Hydroxytriptamine transporter (5HTT)
KW - 5-Hydroxytriptamine transporter gene-linked polymorphic region (5HTTLPR)
KW - Alzheimer's disease (AD)
KW - Polymorphism C
KW - Questionable dementia (QD)
KW - Solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4)
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U2 - 10.1016/j.neulet.2008.04.076
DO - 10.1016/j.neulet.2008.04.076
M3 - Article
C2 - 18490109
AN - SCOPUS:44349166816
VL - 438
SP - 335
EP - 339
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -