Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease

Davide Seripa, Marilisa Franceschi, Grazia D'Onofrio, Francesco Panza, Leandro Cascavilla, Francesco Paris, Giuliana Placentino, Maria Giovanna Matera, Vincenzo Solfrizzi, Alberto Pilotto

Research output: Contribution to journalArticlepeer-review


The promoter region of the serotonin transporter gene (SLC6A4) shows a 22-bp tandem repeat polymorphism, indicated as polymorphism C, that has been associated to depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding its association with Alzheimer's disease (AD). No data were reported regarding its association with questionable dementia (QD). In this study we investigate for polymorphism C in the SLC6A4 gene 302 elderly subjects with a clinical diagnosis of AD (n = 105), QD (n = 88) and no cognitive impairment (n = 114) attending a geriatric ward. A community-dwelling sample of 390 healthy subjects was also included in the analysis. A significant higher prevalence of the C16/C16 genotype in AD than in QD was observed (37.14% vs. 3%; p = 0.041, OR 2.001, 95%CI 1.018-4.024), while no differences in the C16/C14 and C14/C14 genotypes as well as in the estimated allele frequencies were found. No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalNeuroscience Letters
Issue number3
Publication statusPublished - Jun 27 2008


  • 5-Hydroxytriptamine (5HT)
  • 5-Hydroxytriptamine transporter (5HTT)
  • 5-Hydroxytriptamine transporter gene-linked polymorphic region (5HTTLPR)
  • Alzheimer's disease (AD)
  • Polymorphism C
  • Questionable dementia (QD)
  • Solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4)

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease'. Together they form a unique fingerprint.

Cite this