Polymorphism of the 3′-UTR of the dopamine transporter gene (DAT) in New World monkeys

Marco Lucarelli, Elisabetta Visalberghi, Walter Adriani, Elsa Addessi, Silvia Pierandrei, Arianna Manciocco, Francesca Zoratto, Andrea Tamellini, Augusto Vitale, Giovanni Laviola, Jessica Lynch Alfaro, Esterina Pascale

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Genetic polymorphism in the 3′-untranslated region (3′-UTR) of the dopamine transporter (DAT) gene has been reported in both human and nonhuman primates, and the variable number of tandem repeats (VNTR) polymorphism has been related to several neurological and psychiatric disorders. As New World primates have been employed as models in biomedical research in these fields, in the present study we assessed genetic variation in the DAT gene in 25 robust capuchin monkeys (Sapajus spp.) and 39 common marmosets (Callithrix jacchus). Using enzymatic amplification followed by sequencing of amplified fragments, a VNTR polymorphism in the 3′-UTR region of the DAT gene was identified in both robust capuchins and common marmosets. The polymorphic tandem repeat of 40-bp basic units is similar to the human VNTR consensus sequence, with size variants composed of 9, 10, and 11 units in marmosets and 8, 9, 13, and 17 basic units in capuchins. We found behavioral evidence that carrying the 10-repeat DAT allele promotes flexible choice and maximization of foraging in marmosets tested in an operant choice paradigm. Moreover, in an intertemporal choice task, capuchins with longer repeat variants show less self-controlled choices than capuchins with at least one short repeat variant. Future research should focus on the relationship between these DAT polymorphisms, dopamine reuptake via the dopamine transporter, and behavioral and cognitive variation across New World monkey individuals.

Original languageEnglish
Pages (from-to)169-178
Number of pages10
JournalPrimates
Volume58
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Cebidae
3' untranslated regions
dopamine
transporters
genetic polymorphism
Callithrix jacchus
minisatellite repeats
genes
Callitrichidae
Primates
behavior disorders
tandem repeat sequences
nervous system diseases
Cebus
consensus sequence
biomedical research
foraging
alleles
genetic variation

Keywords

  • Callithrix jacchus
  • Common marmoset
  • Dopamine transporter gene
  • Gene polymorphism
  • New World primates
  • Platyrrhini
  • Robust capuchin monkeys
  • Sapajus spp

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Lucarelli, M., Visalberghi, E., Adriani, W., Addessi, E., Pierandrei, S., Manciocco, A., ... Pascale, E. (2017). Polymorphism of the 3′-UTR of the dopamine transporter gene (DAT) in New World monkeys. Primates, 58(1), 169-178. https://doi.org/10.1007/s10329-016-0560-0

Polymorphism of the 3′-UTR of the dopamine transporter gene (DAT) in New World monkeys. / Lucarelli, Marco; Visalberghi, Elisabetta; Adriani, Walter; Addessi, Elsa; Pierandrei, Silvia; Manciocco, Arianna; Zoratto, Francesca; Tamellini, Andrea; Vitale, Augusto; Laviola, Giovanni; Alfaro, Jessica Lynch; Pascale, Esterina.

In: Primates, Vol. 58, No. 1, 01.01.2017, p. 169-178.

Research output: Contribution to journalArticle

Lucarelli, M, Visalberghi, E, Adriani, W, Addessi, E, Pierandrei, S, Manciocco, A, Zoratto, F, Tamellini, A, Vitale, A, Laviola, G, Alfaro, JL & Pascale, E 2017, 'Polymorphism of the 3′-UTR of the dopamine transporter gene (DAT) in New World monkeys', Primates, vol. 58, no. 1, pp. 169-178. https://doi.org/10.1007/s10329-016-0560-0
Lucarelli M, Visalberghi E, Adriani W, Addessi E, Pierandrei S, Manciocco A et al. Polymorphism of the 3′-UTR of the dopamine transporter gene (DAT) in New World monkeys. Primates. 2017 Jan 1;58(1):169-178. https://doi.org/10.1007/s10329-016-0560-0
Lucarelli, Marco ; Visalberghi, Elisabetta ; Adriani, Walter ; Addessi, Elsa ; Pierandrei, Silvia ; Manciocco, Arianna ; Zoratto, Francesca ; Tamellini, Andrea ; Vitale, Augusto ; Laviola, Giovanni ; Alfaro, Jessica Lynch ; Pascale, Esterina. / Polymorphism of the 3′-UTR of the dopamine transporter gene (DAT) in New World monkeys. In: Primates. 2017 ; Vol. 58, No. 1. pp. 169-178.
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