Polymorphism, pseudopolymorphism, and amorphism of peracetylated α-, β-, and γ-cyclodextrins

Giampiero Bettinetti, Milena Sorrenti, Laura Catenacci, Franca Ferrari, Silvia Rossi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Polymorphism, pseudopolymorphism, and amorphism of hexakis(2,3,6-tri-O-acetyl)-α-cyclodextrin (TAαCyD), heptakis(2,3,6-tri-O-acetyl)-β-cyclodextrin (TAβCyD), and octakis(2,3,6-tri-O-acetyl)-γ-cyclodextrin (TAγCyD) were investigated using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffractometry (XRPD), Fourier transform infrared spectroscopy (FTIR) and optical microscopy. An anhydrous and a bi-hydrate crystalline forms of TAαCyD, two monotropic anhydrous polymorphs and three pseudopolymorphs (i.e. methanolate, hydrate, and isopropanolate-hydrate) of TAβCyD, as well as two monotropic anhydrous polymorphs and isostructural pseudopolymorphs (e.g. hydrate and isopropanolate-hydrate) of TAγCyD were isolated and characterized. The amorphous forms of each TACyD were also obtained. Thermal data for desolvation of TAαCyD·2H2O and TAβCyD·CH3OH were reconciled with their crystal packing features. Melting temperatures and enthalpies of the crystalline forms of each TACyD can be referred to for possible solid-state interactions with drugs.

Original languageEnglish
Pages (from-to)1205-1211
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume41
Issue number4
DOIs
Publication statusPublished - Jun 16 2006

Fingerprint

Cyclodextrins
Polymorphism
Hydrates
Crystalline materials
Differential Scanning Calorimetry
Fourier Transform Infrared Spectroscopy
Drug Interactions
Powders
X ray diffraction analysis
Freezing
Optical microscopy
Melting point
Thermogravimetric analysis
Microscopy
Differential scanning calorimetry
Enthalpy
Hot Temperature
X-Rays
Crystals
Temperature

Keywords

  • Differential scanning calorimetry
  • Fourier transform infrared spectroscopy
  • Microscopic analysis
  • Peracetylated cyclodextrins solid-state forms
  • Powder X-ray diffractometry
  • Thermogravimetric analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

Polymorphism, pseudopolymorphism, and amorphism of peracetylated α-, β-, and γ-cyclodextrins. / Bettinetti, Giampiero; Sorrenti, Milena; Catenacci, Laura; Ferrari, Franca; Rossi, Silvia.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 41, No. 4, 16.06.2006, p. 1205-1211.

Research output: Contribution to journalArticle

Bettinetti, Giampiero ; Sorrenti, Milena ; Catenacci, Laura ; Ferrari, Franca ; Rossi, Silvia. / Polymorphism, pseudopolymorphism, and amorphism of peracetylated α-, β-, and γ-cyclodextrins. In: Journal of Pharmaceutical and Biomedical Analysis. 2006 ; Vol. 41, No. 4. pp. 1205-1211.
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