Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients

Federica Torricelli, Vincenzo Dario Mandato, Enrico Farnetti, Martino Abrate, Bruno Casali, Gino Ciarlini, Debora Pirillo, Maria Carolina Gelli, Luigi Costagliola, Davide Nicoli, Stefano Palomba, Giovanni Battista La Sala

Research output: Contribution to journalArticlepeer-review

Abstract

The enzyme cyclooxygenase 2 is an inducible enzyme expressed at sites of inflammation and in a variety of malignant solid tumors such as endometrial cancer (EC). In EC patients, its over-expression is correlated with progressive disease and poor prognosis. The expression is encoded by a polymorphic gene, called PTGS2. The aim of the current study was to test the hypothesis that rs5275 polymorphism of PTGS2 influence the prognosis of EC patients. This paper is a retrospective cohort study. Clinical and pathological data were extrapolated and genotypes were assessed on formalin-fixed and paraffin-embedded non-tumor tissues. A total of 159 type I EC patients were included in the final analysis. Univariate analysis indicated that patients with rs5275 genotype CC have a lower risk to develop a grade (G) 2–3 endometrial cancer. rs5275 effect on EC grading was confirmed by multivariate analysis also after data adjusting for age, BMI, parity, hypertension, and diabetes. Adjusted odds ratio (OR) confirmed that patients with rs5275 genotype CC have a risk 80 % lower (OR = 0.20, P = 0.009) to develop a G2 and/or G3 EC in comparison with patients with TT or TC genotype. Differentiation of the type 1 EC is significantly and independently influenced by rs5275 polymorphism. rs5275 CC patients have a lower risk to present a G2–G3 EC.

Original languageEnglish
Pages (from-to)7423-7430
Number of pages8
JournalTumor Biology
Volume36
Issue number10
DOIs
Publication statusPublished - Apr 22 2015

Keywords

  • COX 2
  • Endometrial cancer
  • Grading
  • PTGS2
  • rs5275

ASJC Scopus subject areas

  • Cancer Research
  • Medicine(all)

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