TY - JOUR
T1 - Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients
AU - Torricelli, Federica
AU - Mandato, Vincenzo Dario
AU - Farnetti, Enrico
AU - Abrate, Martino
AU - Casali, Bruno
AU - Ciarlini, Gino
AU - Pirillo, Debora
AU - Gelli, Maria Carolina
AU - Costagliola, Luigi
AU - Nicoli, Davide
AU - Palomba, Stefano
AU - La Sala, Giovanni Battista
PY - 2015/4/22
Y1 - 2015/4/22
N2 - The enzyme cyclooxygenase 2 is an inducible enzyme expressed at sites of inflammation and in a variety of malignant solid tumors such as endometrial cancer (EC). In EC patients, its over-expression is correlated with progressive disease and poor prognosis. The expression is encoded by a polymorphic gene, called PTGS2. The aim of the current study was to test the hypothesis that rs5275 polymorphism of PTGS2 influence the prognosis of EC patients. This paper is a retrospective cohort study. Clinical and pathological data were extrapolated and genotypes were assessed on formalin-fixed and paraffin-embedded non-tumor tissues. A total of 159 type I EC patients were included in the final analysis. Univariate analysis indicated that patients with rs5275 genotype CC have a lower risk to develop a grade (G) 2–3 endometrial cancer. rs5275 effect on EC grading was confirmed by multivariate analysis also after data adjusting for age, BMI, parity, hypertension, and diabetes. Adjusted odds ratio (OR) confirmed that patients with rs5275 genotype CC have a risk 80 % lower (OR = 0.20, P = 0.009) to develop a G2 and/or G3 EC in comparison with patients with TT or TC genotype. Differentiation of the type 1 EC is significantly and independently influenced by rs5275 polymorphism. rs5275 CC patients have a lower risk to present a G2–G3 EC.
AB - The enzyme cyclooxygenase 2 is an inducible enzyme expressed at sites of inflammation and in a variety of malignant solid tumors such as endometrial cancer (EC). In EC patients, its over-expression is correlated with progressive disease and poor prognosis. The expression is encoded by a polymorphic gene, called PTGS2. The aim of the current study was to test the hypothesis that rs5275 polymorphism of PTGS2 influence the prognosis of EC patients. This paper is a retrospective cohort study. Clinical and pathological data were extrapolated and genotypes were assessed on formalin-fixed and paraffin-embedded non-tumor tissues. A total of 159 type I EC patients were included in the final analysis. Univariate analysis indicated that patients with rs5275 genotype CC have a lower risk to develop a grade (G) 2–3 endometrial cancer. rs5275 effect on EC grading was confirmed by multivariate analysis also after data adjusting for age, BMI, parity, hypertension, and diabetes. Adjusted odds ratio (OR) confirmed that patients with rs5275 genotype CC have a risk 80 % lower (OR = 0.20, P = 0.009) to develop a G2 and/or G3 EC in comparison with patients with TT or TC genotype. Differentiation of the type 1 EC is significantly and independently influenced by rs5275 polymorphism. rs5275 CC patients have a lower risk to present a G2–G3 EC.
KW - COX 2
KW - Endometrial cancer
KW - Grading
KW - PTGS2
KW - rs5275
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U2 - 10.1007/s13277-015-3424-0
DO - 10.1007/s13277-015-3424-0
M3 - Article
C2 - 25900875
AN - SCOPUS:84944279652
VL - 36
SP - 7423
EP - 7430
JO - Tumor Biology
JF - Tumor Biology
SN - 1010-4283
IS - 10
ER -