Polymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population

Ronaldo Celerino da Silva, Ludovica Segat, Valentina Zanin, Luiz Claudio Arraes, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

DC-SIGN and L-SIGN are receptors expressed on specialized macrophages in decidua, (Hofbauer and placental capillary endothelial cells), known to interact with several pathogens, including HIV-1.To disclose the possible involvement of these molecules in the susceptibility to HIV vertical transmission, we analyzed DC-SIGN and L-SIGN gene single nucleotide polymorphisms (SNPs) in 192 HIV-1 positive children and 58 HIV-1 negative children all born to HIV-1 positive mothers, as well as 96 healthy uninfected children not exposed to HIV-1, all from Northeast Brazil.The frequency of three SNPs in the DC-SIGN promoter (-139G. >. A, -201G. >. T and -336A. >. G) were significantly different when comparing HIV positive children with HIV-1 exposed uninfected children, indicating an association with susceptibility to HIV-1 vertical transmission.This genetic association suggests that DC-SIGN molecule may play a role in susceptibility to HIV-1 infection through vertical transmission.

Original languageEnglish
Pages (from-to)1159-1165
Number of pages7
JournalHuman Immunology
Volume73
Issue number11
DOIs
Publication statusPublished - Nov 2012

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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