Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4

Max Leenders, Samsiddhi Bhattacharjee, Paolo Vineis, Victoria Stevens, H. Bas Bueno-De-Mesquita, Xiao Ou Shu, Laufey Amundadottir, Myron Gross, Geoffrey S. Tobias, Jean Wactawski-Wende, Alan A. Arslan, Eric J. Duell, Charles S. Fuchs, Steven Gallinger, Patricia Hartge, Robert N. Hoover, Elizabeth A. Holly, Eric J. Jacobs, Alison P. Klein, Charles KooperbergAndrea Lacroix, Donghui Li, Margaret T. Mandelson, Sara H. Olson, Gloria Petersen, Harvey A. Risch, Kai Yu, Brian M. Wolpin, Wei Zheng, Ilir Agalliu, Demetrius Albanes, Marie Christine Boutron-Ruault, Paige M. Bracci, Julie E. Buring, Federico Canzian, Kenneth Chang, Stephen J. Chanock, Michelle Cotterchio, J. Michael Gaziano, Edward L. Giovanucci, Michael Goggins, Göran Hallmans, Susan E. Hankinson, Judith A. Hoffman-Bolton, David J. Hunter, Amy Hutchinson, Kevin B. Jacobs, Mazda Jenab, Kay Tee Khaw, Peter Kraft, Vittorio Krogh, Robert C. Kurtz, Robert R. McWilliams, Julie B. Mendelsohn, Alpa V. Patel, Kari G. Rabe, Elio Riboli, Anne Tjønneland, Dimitrios Trichopoulos, Jarmo Virtamo, Kala Visvanathan, Joanne W. Elena, Herbert Yu, Anne Zeleniuch-Jacquotte, Rachael Z. Stolzenberg-Solomon

Research output: Contribution to journalArticlepeer-review


Purpose: The evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed. Methods: Using biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (

Original languageEnglish
Pages (from-to)595-602
Number of pages8
JournalCancer Causes and Control
Issue number3
Publication statusPublished - Mar 2013


  • Biomarkers
  • Epidemiology
  • One-carbon metabolism
  • Pancreatic cancer
  • Polymorphisms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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