Abstract
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
Original language | English |
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Pages (from-to) | 121-125 |
Number of pages | 5 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 59 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1 2012 |
Keywords
- Genetics
- HIV-1
- IL-1β
- Inflammasome
- Innate immunity
- NALP3/NLRP3
- Polymorphisms
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)