Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection

Alessandra Pontillo; Telma M. Oshiro; Martina Girardelli; Anselmo J. Kamada; Sergio Crovella; Alberto J S Duarte

doi:10.1097/QAI.0b013e3182392ebe

Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection

Alessandra Pontillo, Telma M. Oshiro, Martina Girardelli, Anselmo J. Kamada, Sergio Crovella, Alberto J S Duarte

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.

Original language	English
Pages (from-to)	121-125
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	59
Issue number	2
DOIs	https://doi.org/10.1097/QAI.0b013e3182392ebe
Publication status	Published - Feb 1 2012

Keywords

Genetics
HIV-1
IL-1β
Inflammasome
Innate immunity
NALP3/NLRP3
Polymorphisms

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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abstract = "The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.",

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AU - Crovella, Sergio

AU - Duarte, Alberto J S

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