Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection

Alessandra Pontillo, Telma M. Oshiro, Martina Girardelli, Anselmo J. Kamada, Sergio Crovella, Alberto J S Duarte

Research output: Contribution to journalArticlepeer-review

Abstract

The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 1 2012

Keywords

  • Genetics
  • HIV-1
  • IL-1β
  • Inflammasome
  • Innate immunity
  • NALP3/NLRP3
  • Polymorphisms

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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