Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition

Antonio Agudo, Núria Sala, Guillem Pera, Gabriel Capellá, Antonio Berenguer, Nadia García, Domenico Palli, Heiner Boeing, Giuseppe Del Giudice, Calogero Saieva, Fatima Carneiro, Franco Berrino, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Roger Stenling, Göran Hallmans, Carmen MartínezRoberto Bilbao, Aurelio Barricarte, Carmen Navarro, José R. Quirós, Naomi Allen, Tim Key, Sheila Bingham, Kay Tee Khaw, Jakob Linseisen, Gabriele Nagel, Kim Overvad, Anne Tjonneland, Anja Olsen, H. Bas Bueno-De-Mesquita, Hendriek C. Boshuizen, Petra H. Peeters, Mattijs E. Numans, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Antonia Trichopoulou, Eiliv Lund, Johan Offerhaus, Mazda Jenab, Pietro Ferrari, Teresa Norat, Elio Riboli, Carlos A. González

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C>A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G>A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis.

Original languageEnglish
Pages (from-to)2427-2434
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Smoke
Stomach Neoplasms
Tobacco
Stomach
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
Genes
Neoplasms
Carcinogenesis
Adenocarcinoma
Alleles
Polycyclic Aromatic Hydrocarbons
Homozygote
Genetic Polymorphisms
Histidine
Case-Control Studies
Odds Ratio
Genotype
Confidence Intervals
DNA

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. / Agudo, Antonio; Sala, Núria; Pera, Guillem; Capellá, Gabriel; Berenguer, Antonio; García, Nadia; Palli, Domenico; Boeing, Heiner; Del Giudice, Giuseppe; Saieva, Calogero; Carneiro, Fatima; Berrino, Franco; Sacerdote, Carlotta; Tumino, Rosario; Panico, Salvatore; Berglund, Göran; Simán, Henrik; Stenling, Roger; Hallmans, Göran; Martínez, Carmen; Bilbao, Roberto; Barricarte, Aurelio; Navarro, Carmen; Quirós, José R.; Allen, Naomi; Key, Tim; Bingham, Sheila; Khaw, Kay Tee; Linseisen, Jakob; Nagel, Gabriele; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Bueno-De-Mesquita, H. Bas; Boshuizen, Hendriek C.; Peeters, Petra H.; Numans, Mattijs E.; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Trichopoulou, Antonia; Lund, Eiliv; Offerhaus, Johan; Jenab, Mazda; Ferrari, Pietro; Norat, Teresa; Riboli, Elio; González, Carlos A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 12, 12.2006, p. 2427-2434.

Research output: Contribution to journalArticle

Agudo, A, Sala, N, Pera, G, Capellá, G, Berenguer, A, García, N, Palli, D, Boeing, H, Del Giudice, G, Saieva, C, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Simán, H, Stenling, R, Hallmans, G, Martínez, C, Bilbao, R, Barricarte, A, Navarro, C, Quirós, JR, Allen, N, Key, T, Bingham, S, Khaw, KT, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Olsen, A, Bueno-De-Mesquita, HB, Boshuizen, HC, Peeters, PH, Numans, ME, Clavel-Chapelon, F, Boutron-Ruault, MC, Trichopoulou, A, Lund, E, Offerhaus, J, Jenab, M, Ferrari, P, Norat, T, Riboli, E & González, CA 2006, 'Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition', Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 12, pp. 2427-2434. https://doi.org/10.1158/1055-9965.EPI-06-0072
Agudo, Antonio ; Sala, Núria ; Pera, Guillem ; Capellá, Gabriel ; Berenguer, Antonio ; García, Nadia ; Palli, Domenico ; Boeing, Heiner ; Del Giudice, Giuseppe ; Saieva, Calogero ; Carneiro, Fatima ; Berrino, Franco ; Sacerdote, Carlotta ; Tumino, Rosario ; Panico, Salvatore ; Berglund, Göran ; Simán, Henrik ; Stenling, Roger ; Hallmans, Göran ; Martínez, Carmen ; Bilbao, Roberto ; Barricarte, Aurelio ; Navarro, Carmen ; Quirós, José R. ; Allen, Naomi ; Key, Tim ; Bingham, Sheila ; Khaw, Kay Tee ; Linseisen, Jakob ; Nagel, Gabriele ; Overvad, Kim ; Tjonneland, Anne ; Olsen, Anja ; Bueno-De-Mesquita, H. Bas ; Boshuizen, Hendriek C. ; Peeters, Petra H. ; Numans, Mattijs E. ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Trichopoulou, Antonia ; Lund, Eiliv ; Offerhaus, Johan ; Jenab, Mazda ; Ferrari, Pietro ; Norat, Teresa ; Riboli, Elio ; González, Carlos A. / Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. In: Cancer Epidemiology Biomarkers and Prevention. 2006 ; Vol. 15, No. 12. pp. 2427-2434.
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AU - Agudo, Antonio

AU - Sala, Núria

AU - Pera, Guillem

AU - Capellá, Gabriel

AU - Berenguer, Antonio

AU - García, Nadia

AU - Palli, Domenico

AU - Boeing, Heiner

AU - Del Giudice, Giuseppe

AU - Saieva, Calogero

AU - Carneiro, Fatima

AU - Berrino, Franco

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Berglund, Göran

AU - Simán, Henrik

AU - Stenling, Roger

AU - Hallmans, Göran

AU - Martínez, Carmen

AU - Bilbao, Roberto

AU - Barricarte, Aurelio

AU - Navarro, Carmen

AU - Quirós, José R.

AU - Allen, Naomi

AU - Key, Tim

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Linseisen, Jakob

AU - Nagel, Gabriele

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Bueno-De-Mesquita, H. Bas

AU - Boshuizen, Hendriek C.

AU - Peeters, Petra H.

AU - Numans, Mattijs E.

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Trichopoulou, Antonia

AU - Lund, Eiliv

AU - Offerhaus, Johan

AU - Jenab, Mazda

AU - Ferrari, Pietro

AU - Norat, Teresa

AU - Riboli, Elio

AU - González, Carlos A.

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