Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction

Licia Iacoviello, Augusto Di Castelnuovo, Peter De Knijff, Andria D'Orazio, Concetta Amore, Rosa Arboretti, Cornelis Kluft, Maria Benedetta Donati

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Background: High blood levels of coagulation factor VII are associated with a risk of ischemic vascular disease. Although factor VII levels may be genetically determined, the relation between genetic polymorphisms of factor VI, factor VII blood levels, and the risk of myocardial infarction has not been established. Methods: We performed a case-control study of 165 patients with familial myocardial infarction (mean ±SD] age, 55±9 years) and 225 controls without a personal or family history of cardiovascular disease (mean age, 56±8 years). The polymorphisms involving R353Q and hypervariable region 4 of the factor VII gene were studied. Factor VII clotting activity and antigen levels were also measured. Results: Patients with the QQ or H7H7 genotype had a decreased risk of myocardial infarction (odds ratios, 0.08 [95 percent confidence interval, 0.01 to 0.9] and 0.22 [95 percent confidence interval, 0.08 to 0.63], respectively). For the R353Q polymorphism, the RR genotype was associated with the highest risk, followed by the RQ genotype and then by the QQ genotype (P

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalNew England Journal of Medicine
Issue number2
Publication statusPublished - Jan 8 1998

ASJC Scopus subject areas

  • Medicine(all)


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