Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression

M. Boniotto, S. Crovella, D. Pirulli, G. Scarlatti, A. Spanò, L. Vatta, S. Zezlina, P. A. Tovo, E. Palomba, A. Amoroso

Research output: Contribution to journalArticle

Abstract

We investigated the polymorphisms of the promoter region of the MBL2 gene, which codifies for the Mannose-binding protein (MBP). The study population included 90 children with vertically acquired HIV-infection, further divided on the basis of the disease rate, 27 HIV exposed-uninfected children, and 74 healthy control subjects matched for ethnic origin to evaluate the MBP involvement in the risk of HIV-1 infection and to assess the role of the MBP promoter in AIDS progression. A region of 380 bp in the promoter of the MBL2 gene was analysed by PCR and direct sequencing of both DNA strands. We found that the polymorphism at position -550 influences the risk of HIV-infection and AIDS progression. Also a 6 bp deletion at position -328 was correlated with HIV-1 infection. This study indicates that the promoter of the MBL2 gene influences vertical transmission of HIV and the course of perinatal infection.

Original languageEnglish
Pages (from-to)346-348
Number of pages3
JournalGenes and Immunity
Volume1
Issue number5
Publication statusPublished - Jun 2000

Fingerprint

Mannose-Binding Lectin
HIV Infections
HIV-1
Acquired Immunodeficiency Syndrome
HIV
Genes
DNA Sequence Analysis
Genetic Promoter Regions
Healthy Volunteers
Polymerase Chain Reaction
Infection
Population

Keywords

  • AIDS progression
  • HIV-1 infection
  • Mannose-binding protein
  • MBL2
  • Promoter region

ASJC Scopus subject areas

  • Genetics
  • Immunology
  • Genetics(clinical)

Cite this

Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression. / Boniotto, M.; Crovella, S.; Pirulli, D.; Scarlatti, G.; Spanò, A.; Vatta, L.; Zezlina, S.; Tovo, P. A.; Palomba, E.; Amoroso, A.

In: Genes and Immunity, Vol. 1, No. 5, 06.2000, p. 346-348.

Research output: Contribution to journalArticle

Boniotto, M, Crovella, S, Pirulli, D, Scarlatti, G, Spanò, A, Vatta, L, Zezlina, S, Tovo, PA, Palomba, E & Amoroso, A 2000, 'Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression', Genes and Immunity, vol. 1, no. 5, pp. 346-348.
Boniotto, M. ; Crovella, S. ; Pirulli, D. ; Scarlatti, G. ; Spanò, A. ; Vatta, L. ; Zezlina, S. ; Tovo, P. A. ; Palomba, E. ; Amoroso, A. / Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression. In: Genes and Immunity. 2000 ; Vol. 1, No. 5. pp. 346-348.
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AU - Spanò, A.

AU - Vatta, L.

AU - Zezlina, S.

AU - Tovo, P. A.

AU - Palomba, E.

AU - Amoroso, A.

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