Polymorphisms of Fas gene: Relationship with Alzheimer's disease and cognitive decline

M. Chiappelli, M. Nasi, A. Cossarizza, E. Porcellini, E. Tumini, M. Pinti, L. Troiano, M. Franceschi, Federico Licastro

Research output: Contribution to journalArticle

Abstract

The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas promoter region with AD patient's cognitive deterioration are reported. The polymorphism at position -1377 was associated with the risk of developing AD and with a differential rate of cognitive decline during a 2-year follow-up. The polymorphism at position -670 was not associated with the risk of AD and with the cognitive decline during the follow-up. Our data suggest that different genetic background in the Fas gene may influence the risk and clinical progression of the disease by affecting neurodegenerative processes leading to neuronal loss.

Original languageEnglish
Pages (from-to)296-300
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume22
Issue number4
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Alzheimer's disease
  • Cognitive decline
  • Fas gene polymorphisms
  • Mini Mental State Examination

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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  • Cite this

    Chiappelli, M., Nasi, M., Cossarizza, A., Porcellini, E., Tumini, E., Pinti, M., Troiano, L., Franceschi, M., & Licastro, F. (2006). Polymorphisms of Fas gene: Relationship with Alzheimer's disease and cognitive decline. Dementia and Geriatric Cognitive Disorders, 22(4), 296-300. https://doi.org/10.1159/000095160