TY - JOUR
T1 - Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk
T2 - A case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Dossus, Laure
AU - McKay, James D.
AU - Canzian, Federico
AU - Wilkening, Stefan
AU - Rinaldi, Sabina
AU - Biessy, Carine
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Jakobsen, Marianne U.
AU - Overvad, Kim
AU - Clavel-Chapelon, Françoise
AU - Boutron-Ruault, Marie Christine
AU - Fournier, Agnes
AU - Linseisen, Jakob
AU - Lukanova, Annekatrin
AU - Boeing, Heiner
AU - Fisher, Eva
AU - Trichopoulou, Antonia
AU - Georgila, Christina
AU - Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Quirós, Ramon José
AU - Sala, Núria
AU - Martínez-García, Carmen
AU - Dorronsoro, Miren
AU - Chirlaque, Maria Dolores
AU - Barricarte, Aurelio
AU - Van Duijnhoven, Fränzel J B
AU - Bueno-de-Mesquita, H. B.
AU - Van Gils, Carla H.
AU - Peeters, Petra H M
AU - Hallmans, Göran
AU - Lenner, Per
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Key, Tim J.
AU - Travis, Ruth C.
AU - Ferrari, Pietro
AU - Jenab, Mazda
AU - Riboli, Elio
AU - Kaaks, Rudolf
PY - 2008
Y1 - 2008
N2 - Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also suggests a role of ghrelin in cancer development. We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. Pair-wise tagging was used to select the 15 polymorphisms that represent the majority of common genetic variants across the GHRL and GHSR genes. A significant increase in breast cancer risk was observed in carriers of the GHRL rs171407-G allele (odds ratio: 1.2; 95% confidence interval: 1.0-1.4; P = 0.02). The GHRL single-nucleotide polymorphism rs375577 was associated with a 5% increase in IGF-I levels (P = 0.01). A number of GHRL and GHSR polymorphisms were associated with body mass index (BMI) and height (P between
AB - Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also suggests a role of ghrelin in cancer development. We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. Pair-wise tagging was used to select the 15 polymorphisms that represent the majority of common genetic variants across the GHRL and GHSR genes. A significant increase in breast cancer risk was observed in carriers of the GHRL rs171407-G allele (odds ratio: 1.2; 95% confidence interval: 1.0-1.4; P = 0.02). The GHRL single-nucleotide polymorphism rs375577 was associated with a 5% increase in IGF-I levels (P = 0.01). A number of GHRL and GHSR polymorphisms were associated with body mass index (BMI) and height (P between
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U2 - 10.1093/carcin/bgn083
DO - 10.1093/carcin/bgn083
M3 - Article
C2 - 18375957
AN - SCOPUS:49349111720
VL - 29
SP - 1360
EP - 1366
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 7
ER -