Abstract
Glutathione S-transferases (GSTs) are a family of enzymes that are known to play an important role in cellular protection against oxidative stress, including the oxidative stress caused by ultraviolet radiation. This study focused on the possible involvement of GSTM1 and GSTT1 polymorphisms in risk modulation of cutaneous melanoma. Within a case-control study, the presence of the null polymorphism at GSTM1 and GSTT1 was investigated in 188 cases of cutaneous melanoma and 152 controls. Information on socio-demographic characteristics, medical history, sun exposure and pigmentary characteristics were collected for all subjects. Logistic regression was used to estimate odds ratio (OR) and 95% confidence intervals (CI). An interaction was suggested between the GSTM1 and GSTT1 "null" genotype and episodes of sunburn in childhood OR of interaction (1.65, 95% CI (95% CI) 0.27-9.94). The risk of melanoma among the subset of participants who reported sunburns in childhood and who had both null variants, was nine (OR 9.16; 95% CI 1.18-70.9). The results suggest that subjects carrying both GSTM1 and GSTT1 null polymorphisms and experiencing sunburns in childhood have an extremely high risk of melanoma.
| Original language | English |
|---|---|
| Pages (from-to) | 284-289 |
| Number of pages | 6 |
| Journal | Acta Dermato-Venereologica |
| Volume | 91 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2011 |
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Keywords
- GSTM1
- GSTT1
- Melanoma
- Sun exposure
ASJC Scopus subject areas
- Dermatology
Cite this
Polymorphisms of GSTM1 and GSTT1, sun exposure and the risk of melanoma : A case-control study. / Fortes, Cristina; Mastroeni, Simona; Boffetta, Paolo; Innocenzi, Luciano; Antonelli, Gianluca; Giovi-Nazzo, Raffaella; Anzidei, Patrizia; Melchi, Franco; D'atri, Stefania; Pasquini, Paolo; Venanzetti, Frederica.
In: Acta Dermato-Venereologica, Vol. 91, No. 3, 05.2011, p. 284-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polymorphisms of GSTM1 and GSTT1, sun exposure and the risk of melanoma
T2 - A case-control study
AU - Fortes, Cristina
AU - Mastroeni, Simona
AU - Boffetta, Paolo
AU - Innocenzi, Luciano
AU - Antonelli, Gianluca
AU - Giovi-Nazzo, Raffaella
AU - Anzidei, Patrizia
AU - Melchi, Franco
AU - D'atri, Stefania
AU - Pasquini, Paolo
AU - Venanzetti, Frederica
PY - 2011/5
Y1 - 2011/5
N2 - Glutathione S-transferases (GSTs) are a family of enzymes that are known to play an important role in cellular protection against oxidative stress, including the oxidative stress caused by ultraviolet radiation. This study focused on the possible involvement of GSTM1 and GSTT1 polymorphisms in risk modulation of cutaneous melanoma. Within a case-control study, the presence of the null polymorphism at GSTM1 and GSTT1 was investigated in 188 cases of cutaneous melanoma and 152 controls. Information on socio-demographic characteristics, medical history, sun exposure and pigmentary characteristics were collected for all subjects. Logistic regression was used to estimate odds ratio (OR) and 95% confidence intervals (CI). An interaction was suggested between the GSTM1 and GSTT1 "null" genotype and episodes of sunburn in childhood OR of interaction (1.65, 95% CI (95% CI) 0.27-9.94). The risk of melanoma among the subset of participants who reported sunburns in childhood and who had both null variants, was nine (OR 9.16; 95% CI 1.18-70.9). The results suggest that subjects carrying both GSTM1 and GSTT1 null polymorphisms and experiencing sunburns in childhood have an extremely high risk of melanoma.
AB - Glutathione S-transferases (GSTs) are a family of enzymes that are known to play an important role in cellular protection against oxidative stress, including the oxidative stress caused by ultraviolet radiation. This study focused on the possible involvement of GSTM1 and GSTT1 polymorphisms in risk modulation of cutaneous melanoma. Within a case-control study, the presence of the null polymorphism at GSTM1 and GSTT1 was investigated in 188 cases of cutaneous melanoma and 152 controls. Information on socio-demographic characteristics, medical history, sun exposure and pigmentary characteristics were collected for all subjects. Logistic regression was used to estimate odds ratio (OR) and 95% confidence intervals (CI). An interaction was suggested between the GSTM1 and GSTT1 "null" genotype and episodes of sunburn in childhood OR of interaction (1.65, 95% CI (95% CI) 0.27-9.94). The risk of melanoma among the subset of participants who reported sunburns in childhood and who had both null variants, was nine (OR 9.16; 95% CI 1.18-70.9). The results suggest that subjects carrying both GSTM1 and GSTT1 null polymorphisms and experiencing sunburns in childhood have an extremely high risk of melanoma.
KW - GSTM1
KW - GSTT1
KW - Melanoma
KW - Sun exposure
UR - http://www.scopus.com/inward/record.url?scp=79955720099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955720099&partnerID=8YFLogxK
U2 - 10.2340/00015555-1078
DO - 10.2340/00015555-1078
M3 - Article
C2 - 21461548
AN - SCOPUS:79955720099
VL - 91
SP - 284
EP - 289
JO - Acta Borealia
JF - Acta Borealia
SN - 0001-5555
IS - 3
ER -