Polymorphisms of HLA class III genes in allergic contact dermatitis

G. Orecchia, L. Perfetti, O. Finco, E. Dondi, M. Cuccia

Research output: Contribution to journalArticlepeer-review


HLA class III polymorphisms (BF, C4A, C4B) were studied in 55 patients of different age and sex suffering from allergic contact dermatitis, with sensitization to different substances. In the overall group of patients no significant correlation between the disease and HLA markers was found. BF F allele was present in 34% and BS S in 64% of patients suffering from allergic contact dermatitis to nickel only versus 16.45% (relative risk, RR=2.61) and 80.76% (RR=0.42), respectively, of the control population. The BF FB subtype frequency was 23.91% versus 7.57% in the control samples (RR=3.88). We thus hypothesize that this polymorphic serum protein might be involved in the pathogenesis of allergic contact dermatitis to nickel.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
Issue number4
Publication statusPublished - 1992


  • Allergic contact dermatitis
  • Complement
  • Human leucocyte antigen class III
  • Major histocompatibility complex
  • Nickel
  • Polymorphisms
  • Properdin factor B

ASJC Scopus subject areas

  • Dermatology

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