TY - JOUR
T1 - Polymorphisms of the CYP1A1, CYP2E1 and XRCC1 genes and cancer risk in a Southern Italian population
T2 - A case-control study
AU - Bianchino, Gabriella
AU - Cittadini, Achille
AU - Grieco, Vitina
AU - Traficante, Antonio
AU - Zupa, Angela
AU - Improta, Giuseppina
AU - Aieta, Michele
AU - Sgambato, Alessandro
PY - 2011/4
Y1 - 2011/4
N2 - Background: Polymorphisms in genes encoding enzymes involved in xenobiotic metabolism andlor in cellular defenses against carcinogen-induced DNA damage play an important role in determining individual cancer susceptibility. However, their distribution and association with cancer susceptibility can vary in different populations. Materials and Methods: A case-control study including 290 cancer patients (cases) and 242 controls was performed to evaluate the relationship between polymorphisms of cytochrome P450 (CYP)1A1 and CYP2E1 and X-ray repair complementing defective repair in Chinese hamster cells (XRCC)1 genes and the risk of developing cancer in a Southern Italian (Basilicata) population. Genomic DNA was isolated from 5 ml whole blood and genotyping was performed using a PCR-RFLP technique. Results: No significant differences were observed in the distribution of the CYP1A1, CYP2E1 and XRCC1 gene polymorphisms between the cases and controls in the population under study. Conclusion: The distribution of CYP1A1, CYP2E1 and XRCC1 gene polymorphisms in the Basilicata population is not different from that of other Italian regions or from that reported in the literature for Caucasian populations, and polymorphisms in these genes do not play an important role in determining cancer risk in the population under study.
AB - Background: Polymorphisms in genes encoding enzymes involved in xenobiotic metabolism andlor in cellular defenses against carcinogen-induced DNA damage play an important role in determining individual cancer susceptibility. However, their distribution and association with cancer susceptibility can vary in different populations. Materials and Methods: A case-control study including 290 cancer patients (cases) and 242 controls was performed to evaluate the relationship between polymorphisms of cytochrome P450 (CYP)1A1 and CYP2E1 and X-ray repair complementing defective repair in Chinese hamster cells (XRCC)1 genes and the risk of developing cancer in a Southern Italian (Basilicata) population. Genomic DNA was isolated from 5 ml whole blood and genotyping was performed using a PCR-RFLP technique. Results: No significant differences were observed in the distribution of the CYP1A1, CYP2E1 and XRCC1 gene polymorphisms between the cases and controls in the population under study. Conclusion: The distribution of CYP1A1, CYP2E1 and XRCC1 gene polymorphisms in the Basilicata population is not different from that of other Italian regions or from that reported in the literature for Caucasian populations, and polymorphisms in these genes do not play an important role in determining cancer risk in the population under study.
KW - Cancer susceptibility
KW - CYP1A1
KW - CYP1E1
KW - DNA-repair genes
KW - Genetic polymorphisms
KW - Metabolizing genes
KW - XRCC1
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M3 - Article
C2 - 21508386
AN - SCOPUS:79956156858
VL - 31
SP - 1359
EP - 1365
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4
ER -