Polymorphisms within inflammatory genes and colorectal cancer

Stefano Landi, Federica Gemignani, Fabio Bottari, Lydie Gioia-Patricola, Elisabet Guino, María Cambray, Sebastiano Biondo, Gabriel Capella, Laura Boldrini, Federico Canzian, Victor Moreno

Research output: Contribution to journalArticle

Abstract

Background: Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain). Results: There was no statistically significant association between the SNPs investigated and colorectal cancer risk. Conclusion: The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size.

Original languageEnglish
Article number15
JournalJournal of Negative Results in BioMedicine
Volume5
DOIs
Publication statusPublished - Oct 24 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Landi, S., Gemignani, F., Bottari, F., Gioia-Patricola, L., Guino, E., Cambray, M., Biondo, S., Capella, G., Boldrini, L., Canzian, F., & Moreno, V. (2006). Polymorphisms within inflammatory genes and colorectal cancer. Journal of Negative Results in BioMedicine, 5, [15]. https://doi.org/10.1186/1477-5751-5-15