Polymorphonuclear leucocyte function during acute viral hepatitis.

A. Lazzarin, M. Galli, F. Caredda, G. Orlando, R. Esposito, F. Franzetti, M. Moroni

Research output: Contribution to journalArticle

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Abstract

Polymorphonuclear (PMN) phagocytosis was tested in three groups of 12 patients (non drug-addicts) hospitalized for acute A, B and non-A, non-B hepatitis. The same test was performed in 12 parenteral drug-addicts (P.D.A.) with non-A, non-B hepatitis, in 12 P.D.A. with type B hepatitis and in 30 P.D.A. without evidence of acute hepatitis. Percent of phagocytosis was evaluated at time of admission to hospital, at discharge and three months after the acute episode. A statistically significant reduction of phagocytosis was present in each of the non-addicts group at time of admission to hospital. At the discharge this reduction was confirmed for type B and non-A, non-B hepatitis, whereas an improvement was noted for type A hepatitis. Control tests carried out 3 months later evidenced that also in patients affected with type B and non-A, non-B hepatitis the percentages of phagocytosis had reached almost normal values. An increased percent of phagocytosis resulted from incubation of patients' PMN with normal human serum. Among drug-addicts the percentages of phagocytosis do not differ from the data recorded in non-addicts patients during the acute stage of the disease. However, three months after the acute episode, a deficit of phagocytic activity was still present in drug-addicts. These data would support the hypothesis that a serum factor impairing the PMN phagocytosis in acute hepatitis is present. Circulating immune complexes were found in the same sera. They might play an important role in inhibitory effect on neutrophils phagocytic activity.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume63
Issue number5
Publication statusPublished - 1984

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Phagocytosis
Hepatitis
Drug Users
Neutrophils
Serum
Acute Disease
Antigen-Antibody Complex
Hepatitis B
Reference Values

ASJC Scopus subject areas

  • Immunology

Cite this

Lazzarin, A., Galli, M., Caredda, F., Orlando, G., Esposito, R., Franzetti, F., & Moroni, M. (1984). Polymorphonuclear leucocyte function during acute viral hepatitis. Bollettino dell'Istituto Sieroterapico Milanese, 63(5), 433-438.

Polymorphonuclear leucocyte function during acute viral hepatitis. / Lazzarin, A.; Galli, M.; Caredda, F.; Orlando, G.; Esposito, R.; Franzetti, F.; Moroni, M.

In: Bollettino dell'Istituto Sieroterapico Milanese, Vol. 63, No. 5, 1984, p. 433-438.

Research output: Contribution to journalArticle

Lazzarin, A, Galli, M, Caredda, F, Orlando, G, Esposito, R, Franzetti, F & Moroni, M 1984, 'Polymorphonuclear leucocyte function during acute viral hepatitis.', Bollettino dell'Istituto Sieroterapico Milanese, vol. 63, no. 5, pp. 433-438.
Lazzarin A, Galli M, Caredda F, Orlando G, Esposito R, Franzetti F et al. Polymorphonuclear leucocyte function during acute viral hepatitis. Bollettino dell'Istituto Sieroterapico Milanese. 1984;63(5):433-438.
Lazzarin, A. ; Galli, M. ; Caredda, F. ; Orlando, G. ; Esposito, R. ; Franzetti, F. ; Moroni, M. / Polymorphonuclear leucocyte function during acute viral hepatitis. In: Bollettino dell'Istituto Sieroterapico Milanese. 1984 ; Vol. 63, No. 5. pp. 433-438.
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