STUDIO DELLA FUNZIONALITA GRANULOCITARIA IN BAMBINI TALASSEMICI

Translated title of the contribution: Polymorphonuclear leukocyte function in thalassemic children

A. Lazzarin, G. Masera, F. Caredda

Research output: Contribution to journalArticle

Abstract

Overhelming infection is a well known complication of splenectomy in Cooley's anemia. A low complement activith has been demonstrated in thalassaemia and this defect could play a role in infections. However, the relationship between polymorphonuclear leucocyte (PMN) function and bacterial infections has not yet been investigated in thalassaemic patients. In the present study, PMN function (phagocytosis, killing, nitroblue tetrazolium reduction) was assessed in 12 splenomegalic and 10 splenectomized thalassaemic patients. PMN's phagocytic and bactericidal activities were detected by the method of Mandell and Hook as modified by Moroni et al. Nitroblue tetrazolium (NBT) reduction by resting and latex-stimulated leukocytes was measured according to the methods of Park et al. and Park and Good as modified by Besana et al. Phagocytosis was significantly impaired only in splenomegalic patients. Intracellular killing and NBT reduction were normal in all patients. It is concluded that sepsis is not related to an impaired PMN function.

Original languageItalian
Pages (from-to)609-612
Number of pages4
JournalRivista Italiana di Pediatria
Volume6
Issue number5
Publication statusPublished - 1980

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Nitroblue Tetrazolium
Neutrophils
Phagocytosis
Thalassemia
beta-Thalassemia
Latex
Splenectomy
Infection
Bacterial Infections
Sepsis
Leukocytes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Lazzarin, A., Masera, G., & Caredda, F. (1980). STUDIO DELLA FUNZIONALITA GRANULOCITARIA IN BAMBINI TALASSEMICI. Rivista Italiana di Pediatria, 6(5), 609-612.

STUDIO DELLA FUNZIONALITA GRANULOCITARIA IN BAMBINI TALASSEMICI. / Lazzarin, A.; Masera, G.; Caredda, F.

In: Rivista Italiana di Pediatria, Vol. 6, No. 5, 1980, p. 609-612.

Research output: Contribution to journalArticle

Lazzarin, A, Masera, G & Caredda, F 1980, 'STUDIO DELLA FUNZIONALITA GRANULOCITARIA IN BAMBINI TALASSEMICI', Rivista Italiana di Pediatria, vol. 6, no. 5, pp. 609-612.
Lazzarin, A. ; Masera, G. ; Caredda, F. / STUDIO DELLA FUNZIONALITA GRANULOCITARIA IN BAMBINI TALASSEMICI. In: Rivista Italiana di Pediatria. 1980 ; Vol. 6, No. 5. pp. 609-612.
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