Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

Antonio Cannatelli, Alfonso Santos-Lopez, Tommaso Giani, Bruno Gonzalez-Zorn, Gian Maria Rossolini

Research output: Contribution to journalArticlepeer-review

Abstract

The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae strains from clinical sources. In this work, we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and mgrB inactivation is not associated with a significant biological cost.

Original languageEnglish
Pages (from-to)2898-2900
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number5
DOIs
Publication statusPublished - May 1 2015

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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