POLYNEUROPATHIE NACH CISPLATIN-BEHANDLUNG

Translated title of the contribution: Polyneuropathey after cis-platinum treatment

C. Meier, A. Goldhirsch, Chr Hess, J. Bazarian, R. Greiner, M. Beer

Research output: Contribution to journalArticle

Abstract

Polyneuropathy developed in 7 of 87 women who had been treated with cis-platinum for ovarian carcinoma. Distal disturbances of sensitivity were clinically prominent, the emphasis being on disturbed vibratory perception and acrognosis. No relevant signs of motor defunctionalisation were noticed, neither clinically nor neurophysiologically. Sural biopsies taken from two women revealed a primary axonal degeneration, mostly affecting the myelinic fibres of large diameter. In 3 cases mild reversion was seen, and in 4 cases no definite reversion, of the disturbed funtions - uncertain gait and clumsiness of the hands - during the follow-up period of 6 to 30 months.

Original languageGerman
Pages (from-to)721-725
Number of pages5
JournalDeutsche Medizinische Wochenschrift
Volume110
Issue number18
Publication statusPublished - 1985

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Meier, C., Goldhirsch, A., Hess, C., Bazarian, J., Greiner, R., & Beer, M. (1985). POLYNEUROPATHIE NACH CISPLATIN-BEHANDLUNG. Deutsche Medizinische Wochenschrift, 110(18), 721-725.