La nefropatia associata all'infezione da polyoma virus BK dopo trapianto renale.

Translated title of the contribution: Polyomavirus BK-associated nephropathy after kidney transplantation

F. Ginevri, A. Azzi, G. Botti, P. Comoli

Research output: Contribution to journalArticlepeer-review

Abstract

Polyomavirus BK (BKV) infection has been lately recognized as a major cause of renal allograft dysfunction. BKV-related interstitial nephropathy (PVAN) may affect 1-10% of renal allograft recipients, occurring more frequently in the first 6 months after transplantation. Progression to irreversible allograft failure has been observed in up to 45% of all cases; thanks to increased PVAN awareness and improved diagnostic techniques, the rate of graft loss has lowered, more consistently in centres with active screening and intervention programs. PVAN pathogenesis is characterized by multiple synergizing factors, among which immunodepression plays a key role. PVAN diagnosis requires the evaluation of a renal biopsy showing polyomavirus cytopathic changes and confirming BKV through an ancillary technique such as immunohistochemistry. Given the focal nature of the disease, early diagnosis may be difficult to obtain. Thus, quantification of BKV-DNA in plasma has been suggested as surrogate marker for PVAN. To date, given the lack of controlled trials, there is no consensus on a 'standard' management of PVAN. However, evidence based on reported observations suggests that a step-wise reduction of immunosuppression, preceded by pulsed steroids in case of coexistent acute rejection, may improve outcomes. Additional options may be represented by drugs with antiviral activity, such as cidofovir, leflunomide or quinolones. Application of a preventive treatment based on viremia monitoring has been recently proposed.

Translated title of the contributionPolyomavirus BK-associated nephropathy after kidney transplantation
Original languageItalian
Pages (from-to)575-584
Number of pages10
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume23
Issue number6
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Nephrology

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