Polypeptide specificity of antiviral serum antibodies in children naturally infected with human rotavirus

H. Brussow, P. A. Offit, G. Gerna, A. Bruttin, J. Sidoti

Research output: Contribution to journalArticle

Abstract

Reassortants between serotype 3 SA11 and serotype 6 NCDV rotaviruses were used to determine the relative amounts of serum-neutralizing antibody to VP4 and VP7 of serotype 3 SA11 rotavirus in children after natural rotavirus exposure. Sera from Ecuadorian children of a population-based study and sera from children of a hospital-based study in Germany (excluding diarrhea patients) demonstrated high titers of VP7-specific but only low titers of VP4-specific antibodies. In contrast, paired sera from German children hospitalized with a symptomatic primary rotavirus gastroenteritis demonstrated a titer increase to VP4 more frequently than to VP7 protein by neutralization test and immunoblotting. For these rotavirus patients, we provided, previously, direct evidence for the development of cross-neutralizing antibodies.

Original languageEnglish
Pages (from-to)4130-4136
Number of pages7
JournalJournal of Virology
Volume64
Issue number9
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Immunology

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