Abstract

As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug–drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.

Original languageEnglish
Pages (from-to)1191-1200
JournalInternal and Emergency Medicine
Volume13
Issue number8
DOIs
Publication statusPublished - 2018

Fingerprint

Polypharmacy
Prescriptions
Internal Medicine
Geriatrics
Population
Comorbidity
Hospitalization
Outpatients
Mortality
Pharmaceutical Preparations

Keywords

  • Deprescribing
  • Inappropriate prescription
  • Medication reconciliation
  • Multimorbidity
  • Polypharmacy

ASJC Scopus subject areas

  • Internal Medicine
  • Emergency Medicine

Cite this

REPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Società Italiana di Medicina Interna) (2018). Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register. Internal and Emergency Medicine, 13(8), 1191-1200. https://doi.org/10.1007/s11739-018-1941-8

Polypharmacy in older people : lessons from 10 years of experience with the REPOSI register. / REPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Società Italiana di Medicina Interna).

In: Internal and Emergency Medicine, Vol. 13, No. 8, 2018, p. 1191-1200.

Research output: Contribution to journalArticle

REPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Società Italiana di Medicina Interna) 2018, 'Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register', Internal and Emergency Medicine, vol. 13, no. 8, pp. 1191-1200. https://doi.org/10.1007/s11739-018-1941-8
REPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Società Italiana di Medicina Interna). Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register. Internal and Emergency Medicine. 2018;13(8):1191-1200. https://doi.org/10.1007/s11739-018-1941-8
REPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Società Italiana di Medicina Interna). / Polypharmacy in older people : lessons from 10 years of experience with the REPOSI register. In: Internal and Emergency Medicine. 2018 ; Vol. 13, No. 8. pp. 1191-1200.
@article{5602344ecb40488a93b85dfeb754eba0,
title = "Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register",
abstract = "As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug–drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Societ{\`a} Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.",
keywords = "Deprescribing, Inappropriate prescription, Medication reconciliation, Multimorbidity, Polypharmacy",
author = "{REPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Societ{\`a} Italiana di Medicina Interna)} and Mannucci, {Pier Mannuccio} and Alessandro Nobili and Luca Pasina and Mannucci, {Pier Mannuccio} and Mauro Tettamanti and Carlotta Franchi and Salvatore Corrao and Alessandra Marengoni and Francesco Salerno and Matteo Cesari and Francesco Perticone and Giuseppe Licata and Francesco Violi and Corazza, {Gino Roberto} and Carlotta Franchi and Laura Cortesi and Mauro Tettamanti and Mauro Bernardi and Mario Barbagallo and Cappellini, {Maria Domenica} and Giovanna Fabio and Matteo Cesari and Rossi, {Paolo Dionigi} and Corazza, {Gino Roberto} and Emanuela Miceli and Giovanni Murialdo and Maria Carbone and Ermanno Angelucci and Rizzo, {Maria Rosaria} and Christian Bracco and Silvia Fargion and Flora Peyvandi and Valter Monzani and Valeria Savojardo and Christian Folli and Francesco Salerno and Bianchi, {Giovanni Battista} and Antonio Mirijello and Marco Bertolotti and Chiara Mussi and Martino, {Giuseppe Pio} and Michele Arcopinto and Marra, {Alberto Maria} and Alberto Ballestrero and Franco Berti and Andrea Artoni and Alberto Tedeschi and Sergio Harari and Chiara Lonati and Mara Cattaneo",
year = "2018",
doi = "10.1007/s11739-018-1941-8",
language = "English",
volume = "13",
pages = "1191--1200",
journal = "Internal and Emergency Medicine",
issn = "1828-0447",
publisher = "Springer-Verlag Italia s.r.l.",
number = "8",

}

TY - JOUR

T1 - Polypharmacy in older people

T2 - lessons from 10 years of experience with the REPOSI register

AU - REPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Società Italiana di Medicina Interna)

AU - Mannucci, Pier Mannuccio

AU - Nobili, Alessandro

AU - Pasina, Luca

AU - Mannucci, Pier Mannuccio

AU - Tettamanti, Mauro

AU - Franchi, Carlotta

AU - Corrao, Salvatore

AU - Marengoni, Alessandra

AU - Salerno, Francesco

AU - Cesari, Matteo

AU - Perticone, Francesco

AU - Licata, Giuseppe

AU - Violi, Francesco

AU - Corazza, Gino Roberto

AU - Franchi, Carlotta

AU - Cortesi, Laura

AU - Tettamanti, Mauro

AU - Bernardi, Mauro

AU - Barbagallo, Mario

AU - Cappellini, Maria Domenica

AU - Fabio, Giovanna

AU - Cesari, Matteo

AU - Rossi, Paolo Dionigi

AU - Corazza, Gino Roberto

AU - Miceli, Emanuela

AU - Murialdo, Giovanni

AU - Carbone, Maria

AU - Angelucci, Ermanno

AU - Rizzo, Maria Rosaria

AU - Bracco, Christian

AU - Fargion, Silvia

AU - Peyvandi, Flora

AU - Monzani, Valter

AU - Savojardo, Valeria

AU - Folli, Christian

AU - Salerno, Francesco

AU - Bianchi, Giovanni Battista

AU - Mirijello, Antonio

AU - Bertolotti, Marco

AU - Mussi, Chiara

AU - Martino, Giuseppe Pio

AU - Arcopinto, Michele

AU - Marra, Alberto Maria

AU - Ballestrero, Alberto

AU - Berti, Franco

AU - Artoni, Andrea

AU - Tedeschi, Alberto

AU - Harari, Sergio

AU - Lonati, Chiara

AU - Cattaneo, Mara

PY - 2018

Y1 - 2018

N2 - As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug–drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.

AB - As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug–drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.

KW - Deprescribing

KW - Inappropriate prescription

KW - Medication reconciliation

KW - Multimorbidity

KW - Polypharmacy

UR - http://www.scopus.com/inward/record.url?scp=85053785528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053785528&partnerID=8YFLogxK

U2 - 10.1007/s11739-018-1941-8

DO - 10.1007/s11739-018-1941-8

M3 - Article

AN - SCOPUS:85053785528

VL - 13

SP - 1191

EP - 1200

JO - Internal and Emergency Medicine

JF - Internal and Emergency Medicine

SN - 1828-0447

IS - 8

ER -