Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study

on behalf of the TOSCA.IT Study Group, Marilena Vitale, Olga Vaccaro, Maria Masulli, Enzo Bonora, Stefano Del Prato, Carlo B Giorda, Antonio Nicolucci, Sebastiano Squatrito, Stefania Auciello, Anna C Babini, Laura Bani, Raffaella Buzzetti, Emanuela Cannarsa, Mauro Cignarelli, Massimo Cigolini, Gennaro Clemente, Sara Cocozza, Laura Corsi, Federica D'Angelo

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The role of polyphenol intake on cardiovascular risk factors is little explored, particularly in people with diabetes. AIM: To evaluate the association between the intake of total polyphenols and polyphenol classes with the major cardiovascular risk factors in a population with type 2 diabetes. METHODS: Dietary habits were investigated in 2573 males and females participants of the TOSCA.IT study. The European Prospective Investigation on Cancer and Nutrition (EPIC) questionnaire was used to assess dietary habits. In all participants, among others, we assessed anthropometry, plasma lipids, blood pressure, C-reactive protein and HbA1c following a standard protocol. The USDA and Phenol-Explorer databases were used to estimate the polyphenol content of the habitual diet. RESULTS: Average intake of polyphenols was 683.3 ± 5.8 mg/day. Flavonoids and phenolic acids were the predominant classes (47.5% and 47.4%, respectively). After adjusting for potential confounders, people with the highest intake of energy-adjusted polyphenols (upper tertile) had a more favorable cardiovascular risk factors profile as compared to people with the lowest intake (lower tertile) (BMI was 30.7 vs 29.9 kg/m2, HDL-cholesterol was 45.1 vs 46.9 mg/dl, LDL-cholesterol was 103.2 vs 102.1 mg/dl, triglycerides were 153.4 vs 148.0 mg/dl, systolic and diastolic blood pressure were respectively 135.3 vs 134.3 and 80.5 vs 79.6 mm/Hg, HbA1c was 7.70 vs 7.67%, and C-reactive Protein was 1.29 vs 1.25 mg/dl, p < .001 for all). The findings were very similar when the analysis was conducted separately for flavonoids or phenolic acids, the two main classes of polyphenols consumed in this population. CONCLUSIONS: Polyphenol intake is associated with a more favorable cardiovascular risk factors profile, independent of major confounders. These findings support the consumption of foods and beverages rich in different classes of polyphenols particularly in people with diabetes. CLINICAL TRIAL: http://www.clinicaltrials.gov; Study ID number: NCT00700856.
Original languageEnglish
Pages (from-to)1686-1692
Number of pages7
JournalClinical Nutrition
Volume36
Issue number6
Publication statusPublished - Dec 2017
Externally publishedYes

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Polyphenols
Type 2 Diabetes Mellitus
Population
Feeding Behavior
Blood Pressure
Flavonoids
C-Reactive Protein
Food and Beverages
United States Department of Agriculture
Anthropometry
Phenol
Energy Intake
LDL Cholesterol
HDL Cholesterol
Triglycerides
Databases
Diet
Lipids

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on behalf of the TOSCA.IT Study Group, Vitale, M., Vaccaro, O., Masulli, M., Bonora, E., Del Prato, S., ... D'Angelo, F. (2017). Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study. Clinical Nutrition, 36(6), 1686-1692.

Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study. / on behalf of the TOSCA.IT Study Group; Vitale, Marilena; Vaccaro, Olga; Masulli, Maria; Bonora, Enzo; Del Prato, Stefano; Giorda, Carlo B; Nicolucci, Antonio; Squatrito, Sebastiano; Auciello, Stefania; Babini, Anna C; Bani, Laura; Buzzetti, Raffaella; Cannarsa, Emanuela; Cignarelli, Mauro; Cigolini, Massimo; Clemente, Gennaro; Cocozza, Sara; Corsi, Laura; D'Angelo, Federica.

In: Clinical Nutrition, Vol. 36, No. 6, 12.2017, p. 1686-1692.

Research output: Contribution to journalArticle

on behalf of the TOSCA.IT Study Group, Vitale, M, Vaccaro, O, Masulli, M, Bonora, E, Del Prato, S, Giorda, CB, Nicolucci, A, Squatrito, S, Auciello, S, Babini, AC, Bani, L, Buzzetti, R, Cannarsa, E, Cignarelli, M, Cigolini, M, Clemente, G, Cocozza, S, Corsi, L & D'Angelo, F 2017, 'Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study', Clinical Nutrition, vol. 36, no. 6, pp. 1686-1692.
on behalf of the TOSCA.IT Study Group, Vitale M, Vaccaro O, Masulli M, Bonora E, Del Prato S et al. Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study. Clinical Nutrition. 2017 Dec;36(6):1686-1692.
on behalf of the TOSCA.IT Study Group ; Vitale, Marilena ; Vaccaro, Olga ; Masulli, Maria ; Bonora, Enzo ; Del Prato, Stefano ; Giorda, Carlo B ; Nicolucci, Antonio ; Squatrito, Sebastiano ; Auciello, Stefania ; Babini, Anna C ; Bani, Laura ; Buzzetti, Raffaella ; Cannarsa, Emanuela ; Cignarelli, Mauro ; Cigolini, Massimo ; Clemente, Gennaro ; Cocozza, Sara ; Corsi, Laura ; D'Angelo, Federica. / Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study. In: Clinical Nutrition. 2017 ; Vol. 36, No. 6. pp. 1686-1692.
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abstract = "BACKGROUND: The role of polyphenol intake on cardiovascular risk factors is little explored, particularly in people with diabetes. AIM: To evaluate the association between the intake of total polyphenols and polyphenol classes with the major cardiovascular risk factors in a population with type 2 diabetes. METHODS: Dietary habits were investigated in 2573 males and females participants of the TOSCA.IT study. The European Prospective Investigation on Cancer and Nutrition (EPIC) questionnaire was used to assess dietary habits. In all participants, among others, we assessed anthropometry, plasma lipids, blood pressure, C-reactive protein and HbA1c following a standard protocol. The USDA and Phenol-Explorer databases were used to estimate the polyphenol content of the habitual diet. RESULTS: Average intake of polyphenols was 683.3 ± 5.8 mg/day. Flavonoids and phenolic acids were the predominant classes (47.5{\%} and 47.4{\%}, respectively). After adjusting for potential confounders, people with the highest intake of energy-adjusted polyphenols (upper tertile) had a more favorable cardiovascular risk factors profile as compared to people with the lowest intake (lower tertile) (BMI was 30.7 vs 29.9 kg/m2, HDL-cholesterol was 45.1 vs 46.9 mg/dl, LDL-cholesterol was 103.2 vs 102.1 mg/dl, triglycerides were 153.4 vs 148.0 mg/dl, systolic and diastolic blood pressure were respectively 135.3 vs 134.3 and 80.5 vs 79.6 mm/Hg, HbA1c was 7.70 vs 7.67{\%}, and C-reactive Protein was 1.29 vs 1.25 mg/dl, p < .001 for all). The findings were very similar when the analysis was conducted separately for flavonoids or phenolic acids, the two main classes of polyphenols consumed in this population. CONCLUSIONS: Polyphenol intake is associated with a more favorable cardiovascular risk factors profile, independent of major confounders. These findings support the consumption of foods and beverages rich in different classes of polyphenols particularly in people with diabetes. CLINICAL TRIAL: http://www.clinicaltrials.gov; Study ID number: NCT00700856.",
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T1 - Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes:

T2 - The TOSCA.IT study

AU - on behalf of the TOSCA.IT Study Group

AU - Vitale, Marilena

AU - Vaccaro, Olga

AU - Masulli, Maria

AU - Bonora, Enzo

AU - Del Prato, Stefano

AU - Giorda, Carlo B

AU - Nicolucci, Antonio

AU - Squatrito, Sebastiano

AU - Auciello, Stefania

AU - Babini, Anna C

AU - Bani, Laura

AU - Buzzetti, Raffaella

AU - Cannarsa, Emanuela

AU - Cignarelli, Mauro

AU - Cigolini, Massimo

AU - Clemente, Gennaro

AU - Cocozza, Sara

AU - Corsi, Laura

AU - D'Angelo, Federica

PY - 2017/12

Y1 - 2017/12

N2 - BACKGROUND: The role of polyphenol intake on cardiovascular risk factors is little explored, particularly in people with diabetes. AIM: To evaluate the association between the intake of total polyphenols and polyphenol classes with the major cardiovascular risk factors in a population with type 2 diabetes. METHODS: Dietary habits were investigated in 2573 males and females participants of the TOSCA.IT study. The European Prospective Investigation on Cancer and Nutrition (EPIC) questionnaire was used to assess dietary habits. In all participants, among others, we assessed anthropometry, plasma lipids, blood pressure, C-reactive protein and HbA1c following a standard protocol. The USDA and Phenol-Explorer databases were used to estimate the polyphenol content of the habitual diet. RESULTS: Average intake of polyphenols was 683.3 ± 5.8 mg/day. Flavonoids and phenolic acids were the predominant classes (47.5% and 47.4%, respectively). After adjusting for potential confounders, people with the highest intake of energy-adjusted polyphenols (upper tertile) had a more favorable cardiovascular risk factors profile as compared to people with the lowest intake (lower tertile) (BMI was 30.7 vs 29.9 kg/m2, HDL-cholesterol was 45.1 vs 46.9 mg/dl, LDL-cholesterol was 103.2 vs 102.1 mg/dl, triglycerides were 153.4 vs 148.0 mg/dl, systolic and diastolic blood pressure were respectively 135.3 vs 134.3 and 80.5 vs 79.6 mm/Hg, HbA1c was 7.70 vs 7.67%, and C-reactive Protein was 1.29 vs 1.25 mg/dl, p < .001 for all). The findings were very similar when the analysis was conducted separately for flavonoids or phenolic acids, the two main classes of polyphenols consumed in this population. CONCLUSIONS: Polyphenol intake is associated with a more favorable cardiovascular risk factors profile, independent of major confounders. These findings support the consumption of foods and beverages rich in different classes of polyphenols particularly in people with diabetes. CLINICAL TRIAL: http://www.clinicaltrials.gov; Study ID number: NCT00700856.

AB - BACKGROUND: The role of polyphenol intake on cardiovascular risk factors is little explored, particularly in people with diabetes. AIM: To evaluate the association between the intake of total polyphenols and polyphenol classes with the major cardiovascular risk factors in a population with type 2 diabetes. METHODS: Dietary habits were investigated in 2573 males and females participants of the TOSCA.IT study. The European Prospective Investigation on Cancer and Nutrition (EPIC) questionnaire was used to assess dietary habits. In all participants, among others, we assessed anthropometry, plasma lipids, blood pressure, C-reactive protein and HbA1c following a standard protocol. The USDA and Phenol-Explorer databases were used to estimate the polyphenol content of the habitual diet. RESULTS: Average intake of polyphenols was 683.3 ± 5.8 mg/day. Flavonoids and phenolic acids were the predominant classes (47.5% and 47.4%, respectively). After adjusting for potential confounders, people with the highest intake of energy-adjusted polyphenols (upper tertile) had a more favorable cardiovascular risk factors profile as compared to people with the lowest intake (lower tertile) (BMI was 30.7 vs 29.9 kg/m2, HDL-cholesterol was 45.1 vs 46.9 mg/dl, LDL-cholesterol was 103.2 vs 102.1 mg/dl, triglycerides were 153.4 vs 148.0 mg/dl, systolic and diastolic blood pressure were respectively 135.3 vs 134.3 and 80.5 vs 79.6 mm/Hg, HbA1c was 7.70 vs 7.67%, and C-reactive Protein was 1.29 vs 1.25 mg/dl, p < .001 for all). The findings were very similar when the analysis was conducted separately for flavonoids or phenolic acids, the two main classes of polyphenols consumed in this population. CONCLUSIONS: Polyphenol intake is associated with a more favorable cardiovascular risk factors profile, independent of major confounders. These findings support the consumption of foods and beverages rich in different classes of polyphenols particularly in people with diabetes. CLINICAL TRIAL: http://www.clinicaltrials.gov; Study ID number: NCT00700856.

M3 - Article

VL - 36

SP - 1686

EP - 1692

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 6

ER -