Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent

Gianfranco Fassina, Anna Buffa, Roberto Benelli, Oliviero E. Varnier, Douglas M. Noonan, Adriana Albini

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Epigallocatechin-3-gallate (EGCG), one of the components of green tea, has been suggested to have antiviral activity. To determine the effects of EGCG on HIV infection, peripheral blood lymphocytes were incubated with either LAI/IIIB or Bal HIV strains and increasing concentrations of EGCG. EGCG strongly inhibited the replication of both virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants.

Original languageEnglish
Pages (from-to)939-941
Number of pages3
JournalAIDS (London, England)
Volume16
Issue number6
DOIs
Publication statusPublished - Apr 12 2002

Fingerprint

Anti-HIV Agents
Tea
Antioxidants
RNA-Directed DNA Polymerase
Virus Replication
HIV Infections
Antiviral Agents
HIV
Lymphocytes
epigallocatechin gallate

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent. / Fassina, Gianfranco; Buffa, Anna; Benelli, Roberto; Varnier, Oliviero E.; Noonan, Douglas M.; Albini, Adriana.

In: AIDS (London, England), Vol. 16, No. 6, 12.04.2002, p. 939-941.

Research output: Contribution to journalArticle

@article{8b3d966580c24b7985b8bcf6671ae920,
title = "Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent",
abstract = "Epigallocatechin-3-gallate (EGCG), one of the components of green tea, has been suggested to have antiviral activity. To determine the effects of EGCG on HIV infection, peripheral blood lymphocytes were incubated with either LAI/IIIB or Bal HIV strains and increasing concentrations of EGCG. EGCG strongly inhibited the replication of both virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants.",
author = "Gianfranco Fassina and Anna Buffa and Roberto Benelli and Varnier, {Oliviero E.} and Noonan, {Douglas M.} and Adriana Albini",
year = "2002",
month = "4",
day = "12",
doi = "10.1097/00002030-200204120-00020",
language = "English",
volume = "16",
pages = "939--941",
journal = "AIDS",
issn = "0269-9370",
publisher = "NLM (Medline)",
number = "6",

}

TY - JOUR

T1 - Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent

AU - Fassina, Gianfranco

AU - Buffa, Anna

AU - Benelli, Roberto

AU - Varnier, Oliviero E.

AU - Noonan, Douglas M.

AU - Albini, Adriana

PY - 2002/4/12

Y1 - 2002/4/12

N2 - Epigallocatechin-3-gallate (EGCG), one of the components of green tea, has been suggested to have antiviral activity. To determine the effects of EGCG on HIV infection, peripheral blood lymphocytes were incubated with either LAI/IIIB or Bal HIV strains and increasing concentrations of EGCG. EGCG strongly inhibited the replication of both virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants.

AB - Epigallocatechin-3-gallate (EGCG), one of the components of green tea, has been suggested to have antiviral activity. To determine the effects of EGCG on HIV infection, peripheral blood lymphocytes were incubated with either LAI/IIIB or Bal HIV strains and increasing concentrations of EGCG. EGCG strongly inhibited the replication of both virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants.

UR - http://www.scopus.com/inward/record.url?scp=0037066377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037066377&partnerID=8YFLogxK

U2 - 10.1097/00002030-200204120-00020

DO - 10.1097/00002030-200204120-00020

M3 - Article

C2 - 11919502

AN - SCOPUS:0037066377

VL - 16

SP - 939

EP - 941

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 6

ER -