Polyphenols and Intestinal Permeability: Rationale and Future Perspectives

Stefano Bernardi, Cristian Del Bo', Mirko Marino, Giorgio Gargari, Antonio Cherubini, Cristina Andrés-Lacueva, Nicole Hidalgo-Liberona, Gregorio Peron, Raúl González-Dominguez, Paul Kroon, Benjamin Kirkup, Marisa Porrini, Simone Guglielmetti, Patrizia Riso

Research output: Contribution to journalReview articlepeer-review


Increasing evidence links intestinal permeability (IP), a feature of the intestinal barrier, to several pathological or dysfunctional conditions. Several host and environmental factors, including dietary factors, can affect the maintenance of normal IP. In this regard, food bioactives, such as polyphenols, have been proposed as potential IP modulators, even if the mechanisms involved are not yet fully elucidated. The aim of the present paper is to provide a short overview of the main evidence from in vitro and in vivo studies supporting the role of polyphenols in modulating IP and briefly discuss future perspectives in this research area.

Original languageEnglish
JournalJournal of Agricultural and Food Chemistry
Publication statusE-pub ahead of print - 2019


  • animal studies
  • human studies
  • in vitro studies
  • intestinal permeability
  • polyphenols

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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