Abstract
Gounaris and colleagues describe a previously unrecognized cross-talk between mast cells and Treg in colon adenomatous polyposis (Gounaris et al., Cancer Res 2009;69:5490-7). Adoptively transferred Treg suppress the focal mastocytosis that fosters tumor initiation and progression. In contrast, endogenous Treg, which abundantly infiltrate polyps, show proinflammatory activity under unknown microenvironmental cues that promote mast cell differentiation and expansion. Compartmentalized Treg plasticity seems to be a key factor in establishing the optimal milieu for cancer development in the intestines. Treg partnership with mast cells recapitulates the complexity of innate-adaptive networks characterizing gut inflammation and represents a novel target for cancer immunotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 5619-5622 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 69 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Jul 15 2009 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Polyps wrap mast cells and Treg within tumorigenic tentacles. / Colombo, Mario P.; Piconese, Silvia.
In: Cancer Research, Vol. 69, No. 14, 15.07.2009, p. 5619-5622.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polyps wrap mast cells and Treg within tumorigenic tentacles
AU - Colombo, Mario P.
AU - Piconese, Silvia
PY - 2009/7/15
Y1 - 2009/7/15
N2 - Gounaris and colleagues describe a previously unrecognized cross-talk between mast cells and Treg in colon adenomatous polyposis (Gounaris et al., Cancer Res 2009;69:5490-7). Adoptively transferred Treg suppress the focal mastocytosis that fosters tumor initiation and progression. In contrast, endogenous Treg, which abundantly infiltrate polyps, show proinflammatory activity under unknown microenvironmental cues that promote mast cell differentiation and expansion. Compartmentalized Treg plasticity seems to be a key factor in establishing the optimal milieu for cancer development in the intestines. Treg partnership with mast cells recapitulates the complexity of innate-adaptive networks characterizing gut inflammation and represents a novel target for cancer immunotherapy.
AB - Gounaris and colleagues describe a previously unrecognized cross-talk between mast cells and Treg in colon adenomatous polyposis (Gounaris et al., Cancer Res 2009;69:5490-7). Adoptively transferred Treg suppress the focal mastocytosis that fosters tumor initiation and progression. In contrast, endogenous Treg, which abundantly infiltrate polyps, show proinflammatory activity under unknown microenvironmental cues that promote mast cell differentiation and expansion. Compartmentalized Treg plasticity seems to be a key factor in establishing the optimal milieu for cancer development in the intestines. Treg partnership with mast cells recapitulates the complexity of innate-adaptive networks characterizing gut inflammation and represents a novel target for cancer immunotherapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=67651002807&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-09-1351
DO - 10.1158/0008-5472.CAN-09-1351
M3 - Article
VL - 69
SP - 5619
EP - 5622
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 14
ER -