Polyps wrap mast cells and Treg within tumorigenic tentacles

Mario P. Colombo, Silvia Piconese

Research output: Contribution to journalArticle

Abstract

Gounaris and colleagues describe a previously unrecognized cross-talk between mast cells and Treg in colon adenomatous polyposis (Gounaris et al., Cancer Res 2009;69:5490-7). Adoptively transferred Treg suppress the focal mastocytosis that fosters tumor initiation and progression. In contrast, endogenous Treg, which abundantly infiltrate polyps, show proinflammatory activity under unknown microenvironmental cues that promote mast cell differentiation and expansion. Compartmentalized Treg plasticity seems to be a key factor in establishing the optimal milieu for cancer development in the intestines. Treg partnership with mast cells recapitulates the complexity of innate-adaptive networks characterizing gut inflammation and represents a novel target for cancer immunotherapy.

Original languageEnglish
Pages (from-to)5619-5622
Number of pages4
JournalCancer Research
Volume69
Issue number14
DOIs
Publication statusPublished - Jul 15 2009

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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