Polysialylated N-CAM, chromogranin A and B, and secretogranin II in neuroendocrine tumours of the lung

Carlo Patriarca, Giancarlo Pruneri, Rosa Maria Alfano, Nadia Carboni, Laura Ermellino, Francesca Guddo, Roberto Buffa, Antonio G. Siccardi, Guido Coggi

Research output: Contribution to journalArticle

Abstract

Highly α2-8-sialylated N-CAM (neural cell adhesion molecule) impairs N-CAM-mediated cell adhesion. We investigated polysiaN-CAM immunoreactivity in a range of neuroendocrine lung tumours: 15 typical carcinoids, 21 atypical carcinoids, 2 large cell neuroendocrine carcinomas and 12 small cell lung carcinomas were selected on a morphological basis and by their immunoreactivity for chromogranin A and B and secretogranin II. A progressive loss of chromogranin expression, particularly of chromogranin B, was paralleled by the up-regulation of polysiaN-CAM in histologically more aggressive tumours (P = 0.001). These data support the hypothesis that loss of cell-cell adhesion properties might be a relevant factor in the origin of the aggressivity of lung neuroendocrine tumours.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalVirchows Archiv
Volume430
Issue number6
DOIs
Publication statusPublished - 1997

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Keywords

  • Chromogranins
  • Lung
  • Neuroendocrine tumours
  • Polysialylated N-CAM

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Patriarca, C., Pruneri, G., Alfano, R. M., Carboni, N., Ermellino, L., Guddo, F., Buffa, R., Siccardi, A. G., & Coggi, G. (1997). Polysialylated N-CAM, chromogranin A and B, and secretogranin II in neuroendocrine tumours of the lung. Virchows Archiv, 430(6), 455-460. https://doi.org/10.1007/s004280050055