Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica

S. Jarius; D. Franciotta; R. Bergamaschi; S. Rauer; K. P. Wandinger; H. F. Petereit; M. Maurer; H. Tumani; A. Vincent; P. Eichhorn; B. Wildemann; M. Wick; R. Voltz

doi:10.1136/jnnp.2007.133330

Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica

S. Jarius, D. Franciotta, R. Bergamaschi, S. Rauer, K. P. Wandinger, H. F. Petereit, M. Maurer, H. Tumani, A. Vincent, P. Eichhorn, B. Wildemann, M. Wick, R. Voltz

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). Aims: To evaluate whether MRZR distinguishes NMO and MS. Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (Al). Results: A positive MRZ reaction, as defined by a combination of at least two positive Als, was found in 37/42 MS, but in only 1/20 NMO patients (p

Original language	English
Pages (from-to)	1134-1136
Number of pages	3
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	79
Issue number	10
DOIs	https://doi.org/10.1136/jnnp.2007.133330
Publication status	Published - Oct 2008

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Surgery

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Jarius, S., Franciotta, D., Bergamaschi, R., Rauer, S., Wandinger, K. P., Petereit, H. F., Maurer, M., Tumani, H., Vincent, A., Eichhorn, P., Wildemann, B., Wick, M., & Voltz, R. (2008). Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica. Journal of Neurology, Neurosurgery and Psychiatry, 79(10), 1134-1136. https://doi.org/10.1136/jnnp.2007.133330

Jarius, S, Franciotta, D , Bergamaschi, R, Rauer, S, Wandinger, KP, Petereit, HF, Maurer, M, Tumani, H, Vincent, A, Eichhorn, P, Wildemann, B, Wick, M & Voltz, R 2008, 'Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica', Journal of Neurology, Neurosurgery and Psychiatry, vol. 79, no. 10, pp. 1134-1136. https://doi.org/10.1136/jnnp.2007.133330

@article{373b829bbe044a45917b7947cff4380e,

title = "Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica",

abstract = "Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). Aims: To evaluate whether MRZR distinguishes NMO and MS. Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (Al). Results: A positive MRZ reaction, as defined by a combination of at least two positive Als, was found in 37/42 MS, but in only 1/20 NMO patients (p",

author = "S. Jarius and D. Franciotta and R. Bergamaschi and S. Rauer and Wandinger, {K. P.} and Petereit, {H. F.} and M. Maurer and H. Tumani and A. Vincent and P. Eichhorn and B. Wildemann and M. Wick and R. Voltz",

year = "2008",

month = oct,

doi = "10.1136/jnnp.2007.133330",

language = "English",

volume = "79",

pages = "1134--1136",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

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T1 - Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica

AU - Jarius, S.

AU - Franciotta, D.

AU - Bergamaschi, R.

AU - Rauer, S.

AU - Wandinger, K. P.

AU - Petereit, H. F.

AU - Maurer, M.

AU - Tumani, H.

AU - Vincent, A.

AU - Eichhorn, P.

AU - Wildemann, B.

AU - Wick, M.

AU - Voltz, R.

PY - 2008/10

Y1 - 2008/10

N2 - Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). Aims: To evaluate whether MRZR distinguishes NMO and MS. Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (Al). Results: A positive MRZ reaction, as defined by a combination of at least two positive Als, was found in 37/42 MS, but in only 1/20 NMO patients (p

AB - Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). Aims: To evaluate whether MRZR distinguishes NMO and MS. Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (Al). Results: A positive MRZ reaction, as defined by a combination of at least two positive Als, was found in 37/42 MS, but in only 1/20 NMO patients (p

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Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica

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