TY - JOUR
T1 - Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica
AU - Jarius, S.
AU - Franciotta, D.
AU - Bergamaschi, R.
AU - Rauer, S.
AU - Wandinger, K. P.
AU - Petereit, H. F.
AU - Maurer, M.
AU - Tumani, H.
AU - Vincent, A.
AU - Eichhorn, P.
AU - Wildemann, B.
AU - Wick, M.
AU - Voltz, R.
PY - 2008/10
Y1 - 2008/10
N2 - Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). Aims: To evaluate whether MRZR distinguishes NMO and MS. Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (Al). Results: A positive MRZ reaction, as defined by a combination of at least two positive Als, was found in 37/42 MS, but in only 1/20 NMO patients (p
AB - Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). Aims: To evaluate whether MRZR distinguishes NMO and MS. Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (Al). Results: A positive MRZ reaction, as defined by a combination of at least two positive Als, was found in 37/42 MS, but in only 1/20 NMO patients (p
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U2 - 10.1136/jnnp.2007.133330
DO - 10.1136/jnnp.2007.133330
M3 - Article
C2 - 18270237
AN - SCOPUS:45549088772
VL - 79
SP - 1134
EP - 1136
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 10
ER -