Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica

S. Jarius, D. Franciotta, R. Bergamaschi, S. Rauer, K. P. Wandinger, H. F. Petereit, M. Maurer, H. Tumani, A. Vincent, P. Eichhorn, B. Wildemann, M. Wick, R. Voltz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). Aims: To evaluate whether MRZR distinguishes NMO and MS. Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (Al). Results: A positive MRZ reaction, as defined by a combination of at least two positive Als, was found in 37/42 MS, but in only 1/20 NMO patients (p

Original languageEnglish
Pages (from-to)1134-1136
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume79
Issue number10
DOIs
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery

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