Polisulfone sterilizzato a vapore e con ossido di etilene: Valutazioni cliniche in pazienti con eosinofilia

Translated title of the contribution: Polysuofone low-flux in eosinophilic patients

G. Ferrari, A. Santoro, A. Francioso, P. Zucchelli, E. Duranti, M. Sasdelli, A. Rosati, M. Salvadori, G. M. Sanna, M. Briganti, M. Fusaroli, G. Lindner, A. Stefani, P. Borgatti, F. Badiali, R. Mignani, L. Cagnoli, F. Aucella, C. Stallone

Research output: Contribution to journalArticlepeer-review


Eosinophilia and some acute dialysis side-effects, such as itching, flushing and bronchospasm, are often associated with the presence of ethylene oxide (ETO) as the dialyzer sterilizing agent. This study evaluates the effects of two different polysulfone (PS) hollow-fiber dialysers sterilized with ETO and steam in 31 chronic dialysis patients with eosinophilia. Clinical symptoms, metabolic and biochemical parameters, complement (C3a and C5a) activation and production were evaluated in each patient dialysed for two months at a time with cuprophane dialyzer, ETO-PS dialyzer and steam-PS dialyzer. The steam-sterilizer agent does not alter the purifying capacity of the PS membrane, which maintains its superiority over cuprophane in terms of biocompatibility. When steam-PS is used, the intradialytic eosinophil kinetics seems to improve. In some patients with high serum levels of ETO-specific IgE these levels tend to diminish. Generic intradialysis symptoms do not differ between the two sterilization methods, although some hypersensitivity symptoms during the first dialysis hour are considerably lower in some patients when steam-sterilized PS is used.

Translated title of the contributionPolysuofone low-flux in eosinophilic patients
Original languageItalian
Pages (from-to)327-335
Number of pages9
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Issue number5
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Nephrology


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