Polyunsaturated fatty acids of germ cell membranes, glutathione and blutathione-dependent enzyme-PHGPx

From basic to clinic

A. Lenzi, L. Gandini, F. Lombardo, M. Picardo, V. Maresca, E. Panfili, F. Tramer, C. Boitani, F. Dondero

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The lipid metabolism in sperm cells is important both for energy production and for cell structure. A special composition of membrane phospholipids, rich in polyunsaturated fatty acids (PUFA), and the different composition of sperm and immature germ cell membrane are described and discussed. Testis germ cells as well as epididymal maturing spermatozoa are endowed with enzymatic and non-enzymatic scavenger systems to prevent lipoperoxidative damage. Catalase, superoxide dismutase, and glutathione-dependent oxidoreductases are present in variable amounts in the different developmental stages. Phospholipid hydroperoxide glutathione peroxidase (PHGPx) activity and roles in caput and cauda epididymal sperm cells are discussed. Also seminal plasma has a highly specialized scavenger system that defends the sperm membrane against lipoperoxidation and the degree of PUFA insaturation acts to achieve the same goal. Systemic predisposition and a number of pathologies can lead to an anti-oxidant/pro-oxidant disequilibrium. Scavengers, such as glutathione can be used to treat these cases as they can restore the physiological constitution of PUFA in the cell membrane.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalContraception
Volume65
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

phospholipid-hydroperoxide glutathione peroxidase
Unsaturated Fatty Acids
Germ Cells
Glutathione
Spermatozoa
Cell Membrane
Enzymes
Membranes
Constitution and Bylaws
Semen
Lipid Metabolism
Oxidants
Catalase
Superoxide Dismutase
Testis
Reactive Oxygen Species
Phospholipids
Oxidoreductases
Pathology

Keywords

  • Immature germ cells
  • Lipoperoxidation
  • PHGPx
  • PUFA
  • ROS
  • Spermatozoa

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

Polyunsaturated fatty acids of germ cell membranes, glutathione and blutathione-dependent enzyme-PHGPx : From basic to clinic. / Lenzi, A.; Gandini, L.; Lombardo, F.; Picardo, M.; Maresca, V.; Panfili, E.; Tramer, F.; Boitani, C.; Dondero, F.

In: Contraception, Vol. 65, No. 4, 2002, p. 301-304.

Research output: Contribution to journalArticle

Lenzi, A. ; Gandini, L. ; Lombardo, F. ; Picardo, M. ; Maresca, V. ; Panfili, E. ; Tramer, F. ; Boitani, C. ; Dondero, F. / Polyunsaturated fatty acids of germ cell membranes, glutathione and blutathione-dependent enzyme-PHGPx : From basic to clinic. In: Contraception. 2002 ; Vol. 65, No. 4. pp. 301-304.
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