Polyunsaturated fatty acids, thrombosis and vascular disease

Giovanni Di Minno, Antonella Tufano, Tiziana Garofano, Matteo Nicola Dario Di Minno

Research output: Contribution to journalArticlepeer-review


In the 80's, retrospective studies showed an inverse relation between fish consumption and ischemic heart disease (IHD) mortality. In parallel, fish fats containing the polyunsaturated fatty acid (PUFA) eicosapentaenoic (EPA) were shown to impair platelet aggregation and thromboxane formation. The results of the large prospective trials, the Diet and Reinfarction Trial (DART) and the Lyon Heart Study in the secondary prevention of myocardial infarction, have further supported the interrelationships between diet and dietary prevention of IHD. In the DART Study, the cardioprotection by EPA was paralleled by an increase plasma content of EPA. In the Lyon, in addition to changes in the content of EPA, changes in other well known variables (i.e. leukocytes and vitamin E), often abnormal in subjects prone to arterial thrombosis, have been found. The GISSI Prevenzione Trial was a prospective, multicentric, open labeled trial with a factorial design, in which 11,324 recent (

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalPathophysiology of Haemostasis and Thrombosis
Issue number5-6
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)


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